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- W4313311023 startingPage "2499" @default.
- W4313311023 abstract "Abstract Specific tolerance of BALB/c spleen cells to phosphorylcholine (PC) was induced in vitro by treatment with antibodies specific for the idiotype of TEPC-15 myeloma protein (anti-T15id) and a PC-containing antigen, R36a. The presence of anti-T15id antibody for at least 2 days was necessary to achieve a full level of suppression (>98%) of anti-PC production in the presence of R36a. The anti-PC response of a nylon wool-separated B cell population was also greatly suppressed (94%) only after a 48-hr treatment with anti-T15id antibody plus antigen. In contrast, either isolated B or unseparated spleen cells treated with anti-T15id alone (without antigen) were fully responsive to PC. Kinetic studies inducated that treatment of cells with anti-T15id antibodies either in the presence or absence of R36a resulted in a gradual suppression of anti-PC responses at a similar rate during an initial 12-hr period. However, further treatment (24 hr) of cells with anti-T15id antibody alone led to recovery of anti-PC response from the suppression, whereas incubation with the anti-idiotype antibody plus R36a induced further suppression. These results indicate that anti-idiotype antibodies can directly inactivate B cells, and this inactivation becomes irreversible only after a continuous exposure to the antibodies in the presence of specific antigen." @default.
- W4313311023 created "2023-01-06" @default.
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- W4313311023 date "1979-12-01" @default.
- W4313311023 modified "2023-10-16" @default.
- W4313311023 title "Mechanisms of Idiotype Suppression" @default.
- W4313311023 doi "https://doi.org/10.4049/jimmunol.123.6.2499" @default.
- W4313311023 hasPublicationYear "1979" @default.
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