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- W4313311044 abstract "Abstract The incubation of zymosan, endotoxin, or immune aggregates with normal human serum activates a factor which induces release of histamine from autologous basophils. The reaction can be divided into two steps: in the first, complement must be activated and in the second, the histamine-releasing factor interacts with basophils. The generation of histamine-releasing activity in serum occurs at 17 to 37°C but not at 0°C, is inhibited by heating the serum at 56°C for 30 min, or by the addition of EDTA to the serum. Once generated, the histamine-liberating activity is stable to heating at 56°C for 30 min. Gel filtration of the activated serum demonstrated that this factor eluted in the same region as a factor with chemotactic activity. Both factors have a molecular weight of about 16,000 daltons and their activities were inhibited by antibody to human C5. This is therefore a pathway for histamine release by C5a where the activation of the basophil is unrelated to the membrane bound IgE." @default.
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- W4313311044 date "1975-04-01" @default.
- W4313311044 modified "2023-10-13" @default.
- W4313311044 title "Complement-Induced Histamine Release from Human Basophils" @default.
- W4313311044 doi "https://doi.org/10.4049/jimmunol.114.4.1185" @default.
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