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- W4313311252 abstract "Abstract 2,4-Dinitrophenyl (DNP) coupled to the copolymer D-glutamic acid and D-lysine (D-GL) induces B cell tolerance but not T cell tolerance. This implies either a lack of DNP determinant recognition by T cells or a substantial difference in tolerance mechanisms for the two cell types. In the present study D-GL was conjugated with the well-defined determinant azobenzenearsonate (ABA) coupled to single amino acids shown here and previously by others to trigger effectively T lymphocytes. The experiments presented here demonstrate that these ABA conjugates of D-GL, although capable of diminishing anti-ABA antibody production, completely fail to render ABA-specific T lymphocytes tolerant thus drawing us to conclude that there are significant operational differences in the mechanisms of tolerance induction in T and B lymphocytes, respectively." @default.
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- W4313311252 date "1975-07-01" @default.
- W4313311252 modified "2023-10-18" @default.
- W4313311252 title "Induction of T Lymphocyte Responses to a Small Molecular Weight Antigen" @default.
- W4313311252 doi "https://doi.org/10.4049/jimmunol.115.1.272" @default.
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