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- W4313311289 endingPage "1926" @default.
- W4313311289 startingPage "1922" @default.
- W4313311289 abstract "Abstract Minor lymphocyte-stimulating (Mls) coded non-H-2-linked lymphocyte-activating determinants (LADs) are present on a late developing subpopulation of murine B lymphocytes. Spleen cells derived from CBA/N mice, a strain with an X-linked defect in B cell function, failed to stimulate a response in Mls-defined mixed lymphocyte reactions (MLRs) with H-2 identical CBA/J or C3H/N responder spleen cells. However, both CBA/J and C3H/N spleen cells induced significant responses in CBA/N responder spleen cells. The inability of CBA/N cells to induce an Mls-defined response was not due to the presence of the nonstimulatory Mlsb genotype, since spleen cells of immunologically normal F1 mice derived from crosses of CBA/N and C3H/N mice were stimulatory in MLRs for C3H/N responder cells. Immunologically abnormal CBA/N ♀ × C3H/N ♂) F1 male mice, which are hemizygous for the CBA/N X chromosome, were also unable to induce a response in Mls-defined MLRs. Although the Mls-coded LADs are not X linked in immunologically normal mouse strains, these data indicate that the failure of CBA/N mice to functionally express the Mls-coded LADs is X linked. This characteristic was not secondary to the presence of suppressor cells and is most likely related to the absence of a late developing (mature) subpopulation of B lymphocytes in these mice." @default.
- W4313311289 created "2023-01-06" @default.
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- W4313311289 date "1976-11-01" @default.
- W4313311289 modified "2023-10-18" @default.
- W4313311289 title "Studies on Non-H-2-Linked Lymphocyte-Activating Determinants" @default.
- W4313311289 doi "https://doi.org/10.4049/jimmunol.117.5_part_2.1922" @default.
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