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- W4313311570 abstract "Abstract Certain antisera to immunoglobulins containing κ-chains show the presence of antibodies that cross-react with β2-microglobulin. This was most apparent with an antiserum made to highly purified F(ab) fragments of Fr II γ-globulin. These cross-reactive antibodies caused positive fluorescence and cytotoxicity reactions with a variety of cell types including T cells. These reactions were completely removed by absorption with highly purified κ-chains but not with λ-chains or λ immunoglobulins. β2-microglobulin preparations also absorbed or inhibited the special cellular reactivities. Evidence was obtained that HLA-bound β2-microglobulin was more efficient in this respect. The possibility is discussed that similar cross-reactive antibodies may have been involved in some previous studies of inhibition of T cell function by immunoglobulin antisera." @default.
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- W4313311570 date "1977-12-01" @default.
- W4313311570 modified "2023-09-27" @default.
- W4313311570 title "A Cross-Reaction between β2-Microglobulin and κ-Light Chains" @default.
- W4313311570 doi "https://doi.org/10.4049/jimmunol.119.6.2001" @default.
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