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- W4313311996 abstract "The determination of the oligomeric state of functional enzymes is essential for the mechanistic understanding of their catalytic activities. RecQ helicases have diverse biochemical activities, but it is still unclear how their activities are related to their oligomeric states. We use single-molecule multi-color fluorescence imaging to determine the oligomeric states of Werner syndrome protein (WRN) during its unwinding and replication fork regression activities. We reveal that WRN binds to a forked DNA as a dimer, and unwinds it without any change of its oligomeric state. In contrast, WRN binds to a replication fork as a tetramer, and is dimerized during activation of replication fork regression. By selectively inhibiting the helicase activity of WRN on specific strands, we reveal how the active dimers of WRN distinctly use the energy of ATP hydrolysis for repetitive unwinding and replication fork regression." @default.
- W4313311996 created "2023-01-06" @default.
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- W4313311996 date "2022-12-30" @default.
- W4313311996 modified "2023-10-05" @default.
- W4313311996 title "Werner syndrome protein works as a dimer for unwinding and replication fork regression" @default.
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- W4313311996 doi "https://doi.org/10.1093/nar/gkac1200" @default.
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