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- W4313312410 abstract "Abstract MGMT , the gene coding for the DNA‐repair protein O 6 ‐methylguanine methyltransferase, which has been recently shown to be a risk factor for inherited forms of Alzheimer's disease (AD), notably among women, might also be linked to Western Pacific amyotrophic lateral sclerosis and Parkinsonism‐dementia complex (ALS/PDC), one phenotype of which is an AD‐like dementia. Guam ALS/PDC is strongly considered to be an environmental disorder caused by oral exposure to natural toxins (i.e., genotoxic/epigenotoxic chemicals), notably methylazoxymethanol (MAM) that alkylates guanine to form O 6 ‐methylguanine, found in the seed of cycad plants traditionally used for food. Thus, the DNA‐repair protein MGMT might participate in both AD and in the AD‐related disorder ALS/PDC." @default.
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- W4313312410 date "2022-12-30" @default.
- W4313312410 modified "2023-10-18" @default.
- W4313312410 title "MGMT, a risk factor for both genetic and environmental forms of dementia" @default.
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- W4313312410 doi "https://doi.org/10.1002/alz.12900" @default.
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