Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313312436> ?p ?o ?g. }
- W4313312436 endingPage "114157" @default.
- W4313312436 startingPage "114157" @default.
- W4313312436 abstract "Association of congestive heart failure (CHF) and chronic kidney disease (CKD) worsens the patient's prognosis and results in poor survival rate. The aim of this study was to examine if addition of endothelin type A (ETA) receptor antagonist to the angiotensin-converting enzyme inhibitor (ACEi) will bring additional beneficial effects in experimental rats.CKD was induced by 5/6 renal mass reduction (5/6 NX) and CHF was elicited by volume overload achieved by creation of aorto-caval fistula (ACF). The follow-up was 24 weeks after the first intervention (5/6 NX). The treatment regimens were initiated 6 weeks after 5/6 NX and 2 weeks after ACF creation.The final survival in untreated group was 15%. The treatment with ETA receptor antagonist alone or ACEi alone and the combined treatment improved the survival rate to 64%, 71% and 75%, respectively, however, the difference between the combination and either single treatment regimen was not significant. The combined treatment exerted best renoprotection, causing additional reduction in albuminuria and reducing renal glomerular and tubulointerstitial injury as compared with ACE inhibition alone.Our results show that treatment with ETA receptor antagonist attenuates the CKD- and CHF-related mortality, and addition of ETA receptor antagonist to the standard blockade of RAS by ACEi exhibits additional renoprotective actions." @default.
- W4313312436 created "2023-01-06" @default.
- W4313312436 creator A5002316775 @default.
- W4313312436 creator A5008801051 @default.
- W4313312436 creator A5031258617 @default.
- W4313312436 creator A5061612754 @default.
- W4313312436 creator A5061685239 @default.
- W4313312436 creator A5070005942 @default.
- W4313312436 creator A5070419819 @default.
- W4313312436 creator A5072638292 @default.
- W4313312436 creator A5078212495 @default.
- W4313312436 creator A5083791579 @default.
- W4313312436 creator A5088651441 @default.
- W4313312436 date "2023-02-01" @default.
- W4313312436 modified "2023-10-18" @default.
- W4313312436 title "Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula" @default.
- W4313312436 cites W1503112713 @default.
- W4313312436 cites W1970800813 @default.
- W4313312436 cites W1994164219 @default.
- W4313312436 cites W1997122776 @default.
- W4313312436 cites W1997785251 @default.
- W4313312436 cites W2014197528 @default.
- W4313312436 cites W2030953256 @default.
- W4313312436 cites W2041439693 @default.
- W4313312436 cites W2059361692 @default.
- W4313312436 cites W2070495296 @default.
- W4313312436 cites W2077196693 @default.
- W4313312436 cites W2138091764 @default.
- W4313312436 cites W2156753852 @default.
- W4313312436 cites W2160802247 @default.
- W4313312436 cites W2162804111 @default.
- W4313312436 cites W2166286573 @default.
- W4313312436 cites W2325540468 @default.
- W4313312436 cites W2409073940 @default.
- W4313312436 cites W2469016668 @default.
- W4313312436 cites W2589391887 @default.
- W4313312436 cites W2596690105 @default.
- W4313312436 cites W2792491339 @default.
- W4313312436 cites W2897504384 @default.
- W4313312436 cites W2902720064 @default.
- W4313312436 cites W2937955146 @default.
- W4313312436 cites W2954018739 @default.
- W4313312436 cites W2969472208 @default.
- W4313312436 cites W2969845228 @default.
- W4313312436 cites W2970685566 @default.
- W4313312436 cites W2972171053 @default.
- W4313312436 cites W2983063065 @default.
- W4313312436 cites W2995632710 @default.
- W4313312436 cites W2996699173 @default.
- W4313312436 cites W2999129752 @default.
- W4313312436 cites W3012083526 @default.
- W4313312436 cites W3140211906 @default.
- W4313312436 cites W3161765141 @default.
- W4313312436 cites W3163720223 @default.
- W4313312436 cites W3193318329 @default.
- W4313312436 cites W3193598686 @default.
- W4313312436 cites W3217029098 @default.
- W4313312436 cites W4205291101 @default.
- W4313312436 cites W4206787050 @default.
- W4313312436 cites W4206831265 @default.
- W4313312436 cites W4210343616 @default.
- W4313312436 cites W4211136945 @default.
- W4313312436 cites W4214848189 @default.
- W4313312436 cites W4229021149 @default.
- W4313312436 cites W4282912740 @default.
- W4313312436 cites W4299627282 @default.
- W4313312436 doi "https://doi.org/10.1016/j.biopha.2022.114157" @default.
- W4313312436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36580726" @default.
- W4313312436 hasPublicationYear "2023" @default.
- W4313312436 type Work @default.
- W4313312436 citedByCount "1" @default.
- W4313312436 countsByYear W43133124362023 @default.
- W4313312436 crossrefType "journal-article" @default.
- W4313312436 hasAuthorship W4313312436A5002316775 @default.
- W4313312436 hasAuthorship W4313312436A5008801051 @default.
- W4313312436 hasAuthorship W4313312436A5031258617 @default.
- W4313312436 hasAuthorship W4313312436A5061612754 @default.
- W4313312436 hasAuthorship W4313312436A5061685239 @default.
- W4313312436 hasAuthorship W4313312436A5070005942 @default.
- W4313312436 hasAuthorship W4313312436A5070419819 @default.
- W4313312436 hasAuthorship W4313312436A5072638292 @default.
- W4313312436 hasAuthorship W4313312436A5078212495 @default.
- W4313312436 hasAuthorship W4313312436A5083791579 @default.
- W4313312436 hasAuthorship W4313312436A5088651441 @default.
- W4313312436 hasBestOaLocation W43133124361 @default.
- W4313312436 hasConcept C126322002 @default.
- W4313312436 hasConcept C126894567 @default.
- W4313312436 hasConcept C134018914 @default.
- W4313312436 hasConcept C144980905 @default.
- W4313312436 hasConcept C164705383 @default.
- W4313312436 hasConcept C170493617 @default.
- W4313312436 hasConcept C24595384 @default.
- W4313312436 hasConcept C27016395 @default.
- W4313312436 hasConcept C2776174234 @default.
- W4313312436 hasConcept C2776345702 @default.
- W4313312436 hasConcept C2776885963 @default.
- W4313312436 hasConcept C2777387769 @default.
- W4313312436 hasConcept C2778122271 @default.