FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313312598> ?p ?o ?g. }

• W4313312598 abstract "CXCR4 is a seven‑transmembrane‑spanning Gi‑coupled receptor for the SDF‑1 chemokine and plays a critical role in cardiovascular development and post‑injury repair. However, the specific role of CXCR4 in cardiomyocytes is incompletely understood. It was hypothesized that CXCR4 activation in cardiomyocytes antagonizes β‑adrenoceptor/Gs signaling‑induced cardiac dysfunction. Cardiomyocyte‑specific CXCR4 knockout (CXCR4‑^CMKO) mice were generated by crossing CXCR4^fl/fl and MHC‑Cre^+/‑ mice. Their cardiac structure and function in the basal state are equivalent to that of the control MHC‑Cre^+/‑ littermates until at least 4 months old. However, following continuous subcutaneous administration of isoproterenol (Iso) via an osmotic mini‑pump, the ventricular myocardial contractility, dilation, cardiomyocyte apoptosis, and interstitial fibrosis are worse in CXCR4‑^CMKO mice than in MHC‑Cre^+/‑ littermates. In the cultured H9C2 cardiomyocytes, SDF‑1 treatment markedly attenuated Iso‑induced apoptosis and reduction in phospho‑Akt, and this protective effect was lost by knockdown of CXCR4 or by co‑treatment with Gi inhibitors. In conclusion, CXCR4 promotes cardiomyocyte survival and heart function during β‑adrenergic stress." @default.
• W4313312598 created "2023-01-06" @default.
• W4313312598 creator A5002322899 @default.
• W4313312598 creator A5025864556 @default.
• W4313312598 creator A5047113750 @default.
• W4313312598 creator A5064665889 @default.
• W4313312598 creator A5079711130 @default.
• W4313312598 creator A5082466693 @default.
• W4313312598 creator A5082679268 @default.
• W4313312598 date "2022-12-29" @default.
• W4313312598 modified "2023-09-25" @default.
• W4313312598 title "Ablation of CXCR4 expression in cardiomyocytes exacerbates isoproterenol‑induced cell death and heart failure" @default.
• W4313312598 cites W1811184201 @default.
• W4313312598 cites W1981963947 @default.
• W4313312598 cites W1983977485 @default.
• W4313312598 cites W2010638326 @default.
• W4313312598 cites W2032955665 @default.
• W4313312598 cites W2061901991 @default.
• W4313312598 cites W2071614910 @default.
• W4313312598 cites W2077425788 @default.
• W4313312598 cites W2081769332 @default.
• W4313312598 cites W2083612980 @default.
• W4313312598 cites W2085368741 @default.
• W4313312598 cites W2087482734 @default.
• W4313312598 cites W2091242522 @default.
• W4313312598 cites W2094657005 @default.
• W4313312598 cites W2100711901 @default.
• W4313312598 cites W2103247295 @default.
• W4313312598 cites W2107277218 @default.
• W4313312598 cites W2110450264 @default.
• W4313312598 cites W2111511937 @default.
• W4313312598 cites W2114196012 @default.
• W4313312598 cites W2117412164 @default.
• W4313312598 cites W2124075001 @default.
• W4313312598 cites W2125103083 @default.
• W4313312598 cites W2125212020 @default.
• W4313312598 cites W2133496200 @default.
• W4313312598 cites W2143063196 @default.
• W4313312598 cites W2151825667 @default.
• W4313312598 cites W2157932674 @default.
• W4313312598 cites W2158800467 @default.
• W4313312598 cites W2165225182 @default.
• W4313312598 cites W2166421867 @default.
• W4313312598 cites W2170252071 @default.
• W4313312598 cites W2192080449 @default.
• W4313312598 cites W2286884701 @default.
• W4313312598 cites W2319534362 @default.
• W4313312598 cites W2321185467 @default.
• W4313312598 cites W2325664829 @default.
• W4313312598 cites W2326508838 @default.
• W4313312598 cites W2333233213 @default.
• W4313312598 cites W2842831319 @default.
• W4313312598 cites W2887386139 @default.
• W4313312598 cites W2889986213 @default.
• W4313312598 cites W2900102239 @default.
• W4313312598 cites W2908256106 @default.
• W4313312598 cites W2914909785 @default.
• W4313312598 cites W2917270161 @default.
• W4313312598 cites W2943921432 @default.
• W4313312598 cites W2951911538 @default.
• W4313312598 cites W2970248343 @default.
• W4313312598 cites W2989075383 @default.
• W4313312598 cites W3043455207 @default.
• W4313312598 cites W3195715815 @default.
• W4313312598 cites W4229759864 @default.
• W4313312598 cites W4281384856 @default.
• W4313312598 cites W4293575041 @default.
• W4313312598 doi "https://doi.org/10.3892/ijmm.2022.5216" @default.
• W4313312598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36579657" @default.
• W4313312598 hasPublicationYear "2022" @default.
• W4313312598 type Work @default.
• W4313312598 citedByCount "0" @default.
• W4313312598 crossrefType "journal-article" @default.
• W4313312598 hasAuthorship W4313312598A5002322899 @default.
• W4313312598 hasAuthorship W4313312598A5025864556 @default.
• W4313312598 hasAuthorship W4313312598A5047113750 @default.
• W4313312598 hasAuthorship W4313312598A5064665889 @default.
• W4313312598 hasAuthorship W4313312598A5079711130 @default.
• W4313312598 hasAuthorship W4313312598A5082466693 @default.
• W4313312598 hasAuthorship W4313312598A5082679268 @default.
• W4313312598 hasBestOaLocation W43133125981 @default.
• W4313312598 hasConcept C111566952 @default.
• W4313312598 hasConcept C126322002 @default.
• W4313312598 hasConcept C134018914 @default.
• W4313312598 hasConcept C185592680 @default.
• W4313312598 hasConcept C190283241 @default.
• W4313312598 hasConcept C207200792 @default.
• W4313312598 hasConcept C2778198053 @default.
• W4313312598 hasConcept C39133596 @default.
• W4313312598 hasConcept C55493867 @default.
• W4313312598 hasConcept C71924100 @default.
• W4313312598 hasConcept C86803240 @default.
• W4313312598 hasConceptScore W4313312598C111566952 @default.
• W4313312598 hasConceptScore W4313312598C126322002 @default.
• W4313312598 hasConceptScore W4313312598C134018914 @default.
• W4313312598 hasConceptScore W4313312598C185592680 @default.
• W4313312598 hasConceptScore W4313312598C190283241 @default.
• W4313312598 hasConceptScore W4313312598C207200792 @default.
• W4313312598 hasConceptScore W4313312598C2778198053 @default.
• W4313312598 hasConceptScore W4313312598C39133596 @default.

• next