FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313312609> ?p ?o ?g. }

• W4313312609 endingPage "105456" @default.
• W4313312609 startingPage "105456" @default.
• W4313312609 abstract "Astrocytes are a distinct population of glial cells responsible for many homeostatic functions in normal neural architecture. In the healthy brain, astrocyte functions range from maintenance of the blood brain barrier to modulation of synaptic transmission and neuronal plasticity to glial scar formation post-ischemic injury. In humans, this group of cells exhibits far greater heterogeneity than previously thought-with distinct subpopulations that likely carry out specialized functions. Following ischemic injury, astrocytes take on a distinct phenotype-known as the reactive astrocyte. This phenotype is responsible for both the propagation and amelioration of neuronal injury during ischemia. Following ischemia, astrocytes undergo temporal and spatial-dependent changes in morphology, gene expression, hypertrophy and hyperplasia as a result of signaling within the local microenvironment of the penumbra compared to the core infarct. This elicits a cascade of downstream effects, including inflammation and activation of the innate immune system, which both propagates and ameliorates local injury within the brain parenchyma. This review will focus upon the double-edged sword-that are astrocytes and the innate immune system. We will discuss the role that astrocytes and the innate immune system play in amplifying secondary brain injury, as well as attenuating ischemic damage. Specifically, we will focus on molecular signaling and processes that could be targeted as potential therapeutic interventions." @default.
• W4313312609 created "2023-01-06" @default.
• W4313312609 creator A5008916537 @default.
• W4313312609 creator A5053444223 @default.
• W4313312609 creator A5058817882 @default.
• W4313312609 date "2023-01-01" @default.
• W4313312609 modified "2023-09-27" @default.
• W4313312609 title "Astrocyte innate immune activation and injury amplification following experimental focal cerebral ischemia" @default.
• W4313312609 cites W1514824226 @default.
• W4313312609 cites W1534620902 @default.
• W4313312609 cites W1969305530 @default.
• W4313312609 cites W1970901436 @default.
• W4313312609 cites W1979228875 @default.
• W4313312609 cites W1989591516 @default.
• W4313312609 cites W1992458428 @default.
• W4313312609 cites W1999004826 @default.
• W4313312609 cites W2008283809 @default.
• W4313312609 cites W2019475666 @default.
• W4313312609 cites W2020622209 @default.
• W4313312609 cites W2022533963 @default.
• W4313312609 cites W2035221144 @default.
• W4313312609 cites W2040787182 @default.
• W4313312609 cites W2047436581 @default.
• W4313312609 cites W2047585900 @default.
• W4313312609 cites W2048047884 @default.
• W4313312609 cites W2048329840 @default.
• W4313312609 cites W2050382124 @default.
• W4313312609 cites W2056103140 @default.
• W4313312609 cites W2063751623 @default.
• W4313312609 cites W2065802840 @default.
• W4313312609 cites W2071973579 @default.
• W4313312609 cites W2074342738 @default.
• W4313312609 cites W2085424855 @default.
• W4313312609 cites W2103420764 @default.
• W4313312609 cites W2108204976 @default.
• W4313312609 cites W2121860798 @default.
• W4313312609 cites W2143000970 @default.
• W4313312609 cites W2146571284 @default.
• W4313312609 cites W2157903932 @default.
• W4313312609 cites W2159592906 @default.
• W4313312609 cites W2400419369 @default.
• W4313312609 cites W2402583598 @default.
• W4313312609 cites W2542414179 @default.
• W4313312609 cites W2572710398 @default.
• W4313312609 cites W2700330585 @default.
• W4313312609 cites W2923363662 @default.
• W4313312609 cites W2934990819 @default.
• W4313312609 cites W2971712052 @default.
• W4313312609 cites W3008535867 @default.
• W4313312609 cites W3128873701 @default.
• W4313312609 cites W3132240972 @default.
• W4313312609 cites W3182888764 @default.
• W4313312609 cites W3192633652 @default.
• W4313312609 cites W3213004408 @default.
• W4313312609 doi "https://doi.org/10.1016/j.neuint.2022.105456" @default.
• W4313312609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36509233" @default.
• W4313312609 hasPublicationYear "2023" @default.
• W4313312609 type Work @default.
• W4313312609 citedByCount "0" @default.
• W4313312609 crossrefType "journal-article" @default.
• W4313312609 hasAuthorship W4313312609A5008916537 @default.
• W4313312609 hasAuthorship W4313312609A5053444223 @default.
• W4313312609 hasAuthorship W4313312609A5058817882 @default.
• W4313312609 hasConcept C126322002 @default.
• W4313312609 hasConcept C136449434 @default.
• W4313312609 hasConcept C169760540 @default.
• W4313312609 hasConcept C203014093 @default.
• W4313312609 hasConcept C2776914184 @default.
• W4313312609 hasConcept C2777542381 @default.
• W4313312609 hasConcept C2779830541 @default.
• W4313312609 hasConcept C2780577055 @default.
• W4313312609 hasConcept C529278444 @default.
• W4313312609 hasConcept C541997718 @default.
• W4313312609 hasConcept C71924100 @default.
• W4313312609 hasConcept C86803240 @default.
• W4313312609 hasConcept C8891405 @default.
• W4313312609 hasConceptScore W4313312609C126322002 @default.
• W4313312609 hasConceptScore W4313312609C136449434 @default.
• W4313312609 hasConceptScore W4313312609C169760540 @default.
• W4313312609 hasConceptScore W4313312609C203014093 @default.
• W4313312609 hasConceptScore W4313312609C2776914184 @default.
• W4313312609 hasConceptScore W4313312609C2777542381 @default.
• W4313312609 hasConceptScore W4313312609C2779830541 @default.
• W4313312609 hasConceptScore W4313312609C2780577055 @default.
• W4313312609 hasConceptScore W4313312609C529278444 @default.
• W4313312609 hasConceptScore W4313312609C541997718 @default.
• W4313312609 hasConceptScore W4313312609C71924100 @default.
• W4313312609 hasConceptScore W4313312609C86803240 @default.
• W4313312609 hasConceptScore W4313312609C8891405 @default.
• W4313312609 hasLocation W43133126091 @default.
• W4313312609 hasLocation W43133126092 @default.
• W4313312609 hasOpenAccess W4313312609 @default.
• W4313312609 hasPrimaryLocation W43133126091 @default.
• W4313312609 hasRelatedWork W2011225171 @default.
• W4313312609 hasRelatedWork W2056767671 @default.
• W4313312609 hasRelatedWork W2387770071 @default.
• W4313312609 hasRelatedWork W2988640276 @default.
• W4313312609 hasRelatedWork W3005292279 @default.

• next