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• W4313312697 abstract "Necroptosis is a unique programmed death mechanism of necrotic cells. However, its role and specific mechanism in cancer remain unclear, and a systematic pan-cancer analysis of necroptosis is yet to be conducted. Thus, we performed a specific pan-cancer analysis using The Cancer Genome Atlas and Genotype-Tissue Expression databases to analyse necroptosis expression in terms of cancer prognosis, DNA methylation status, tumour mutative burden, microsatellite instability, immune cell infiltration in different types of cancer and molecular mechanisms. For the first time, we explored the correlation between necroptosis and immunotherapy prognosis. Thus, our study provides a relatively comprehensive understanding of the carcinogenicity of necroptosis in different types of cancer. It is suggested that necroptosis can be used to evaluate the sensitivity of different patients to immunotherapy and may become a potential target for tumour immunotherapy." @default.
• W4313312697 created "2023-01-06" @default.
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• W4313312697 date "2022-12-29" @default.
• W4313312697 modified "2023-09-26" @default.
• W4313312697 title "<scp>Pan‐Cancer</scp> analyses of <scp>Necroptosis‐Related</scp> genes as a potential target to predict immunotherapeutic outcome" @default.
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• W4313312697 doi "https://doi.org/10.1111/jcmm.17634" @default.
• W4313312697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36583248" @default.
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