FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313312918> ?p ?o ?g. }

• W4313312918 endingPage "83" @default.
• W4313312918 startingPage "72" @default.
• W4313312918 abstract "Globally, spinal cord injury (SCI) results in a big burden, including 90% suffering permanent disability, and 60%-69% experiencing neuropathic pain. The main causes are oxidative stress, inflammation, and degeneration. The efficacy of the stem cell secretome is promising, but the role of human neural stem cell (HNSC)-secretome in neuropathic pain is unclear. This study evaluated how the mechanism of HNSC-secretome improves neuropathic pain and locomotor function in SCI rat models through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities.A proper experimental study investigated 15 Rattus norvegicus divided into normal, control, and treatment groups (30 μL HNSC-secretome, intrathecal in the level of T10, three days post-traumatic SCI). Twenty-eight days post-injury, specimens were collected, and matrix metalloproteinase (MMP)-9, F2-Isoprostanes, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, and brain derived neurotrophic factor (BDNF) were analyzed. Locomotor recovery was evaluated via Basso, Beattie, and Bresnahan scores. Neuropathic pain was evaluated using the Rat Grimace Scale.The HNSC-secretome could improve locomotor recovery and neuropathic pain, decrease F2-Isoprostane (antioxidant), decrease MMP-9 and TNF-α (anti-inflammatory), as well as modulate TGF-β and BDNF (neurotrophic factor). Moreover, HNSC-secretomes maintain the extracellular matrix of SCI by reducing the matrix degradation effect of MMP-9 and increasing the collagen formation effect of TGF-β as a resistor of glial scar formation.The present study demonstrated the mechanism of HNSC-secretome in improving neuropathic pain and locomotor function in SCI through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities." @default.
• W4313312918 created "2023-01-06" @default.
• W4313312918 creator A5016060784 @default.
• W4313312918 creator A5043899526 @default.
• W4313312918 creator A5046841965 @default.
• W4313312918 creator A5061446239 @default.
• W4313312918 creator A5077299589 @default.
• W4313312918 date "2022-12-23" @default.
• W4313312918 modified "2023-10-03" @default.
• W4313312918 title "The mechanism of human neural stem cell secretomes improves neuropathic pain and locomotor function in spinal cord injury rat models: through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities" @default.
• W4313312918 cites W1964335763 @default.
• W4313312918 cites W2006588930 @default.
• W4313312918 cites W2010175048 @default.
• W4313312918 cites W2012396390 @default.
• W4313312918 cites W2015116639 @default.
• W4313312918 cites W2047478886 @default.
• W4313312918 cites W2047724409 @default.
• W4313312918 cites W2051021959 @default.
• W4313312918 cites W2057133274 @default.
• W4313312918 cites W2071524012 @default.
• W4313312918 cites W2075700793 @default.
• W4313312918 cites W2081552068 @default.
• W4313312918 cites W2085988912 @default.
• W4313312918 cites W2132417596 @default.
• W4313312918 cites W2150026933 @default.
• W4313312918 cites W2157878405 @default.
• W4313312918 cites W2167885395 @default.
• W4313312918 cites W2170645579 @default.
• W4313312918 cites W2337694833 @default.
• W4313312918 cites W2338229883 @default.
• W4313312918 cites W2417761185 @default.
• W4313312918 cites W2468124354 @default.
• W4313312918 cites W2510712453 @default.
• W4313312918 cites W2511009367 @default.
• W4313312918 cites W2518592417 @default.
• W4313312918 cites W2565008284 @default.
• W4313312918 cites W2594400424 @default.
• W4313312918 cites W2608611322 @default.
• W4313312918 cites W2770090545 @default.
• W4313312918 cites W2801559469 @default.
• W4313312918 cites W2888361091 @default.
• W4313312918 cites W2925177128 @default.
• W4313312918 cites W2950423533 @default.
• W4313312918 cites W2955503221 @default.
• W4313312918 cites W2972437803 @default.
• W4313312918 cites W2983559674 @default.
• W4313312918 cites W2991323130 @default.
• W4313312918 cites W2998530317 @default.
• W4313312918 cites W3014849362 @default.
• W4313312918 cites W3088704361 @default.
• W4313312918 cites W3093434759 @default.
• W4313312918 cites W3097438161 @default.
• W4313312918 cites W3112690360 @default.
• W4313312918 cites W3177517027 @default.
• W4313312918 cites W3204590920 @default.
• W4313312918 cites W3213243042 @default.
• W4313312918 cites W4225098474 @default.
• W4313312918 cites W4283717244 @default.
• W4313312918 cites W4283730234 @default.
• W4313312918 cites W4283733458 @default.
• W4313312918 doi "https://doi.org/10.3344/kjp.22279" @default.
• W4313312918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36549874" @default.
• W4313312918 hasPublicationYear "2022" @default.
• W4313312918 type Work @default.
• W4313312918 citedByCount "3" @default.
• W4313312918 countsByYear W43133129182023 @default.
• W4313312918 crossrefType "journal-article" @default.
• W4313312918 hasAuthorship W4313312918A5016060784 @default.
• W4313312918 hasAuthorship W4313312918A5043899526 @default.
• W4313312918 hasAuthorship W4313312918A5046841965 @default.
• W4313312918 hasAuthorship W4313312918A5061446239 @default.
• W4313312918 hasAuthorship W4313312918A5077299589 @default.
• W4313312918 hasBestOaLocation W43133129181 @default.
• W4313312918 hasConcept C118552586 @default.
• W4313312918 hasConcept C126322002 @default.
• W4313312918 hasConcept C136834591 @default.
• W4313312918 hasConcept C160539049 @default.
• W4313312918 hasConcept C170493617 @default.
• W4313312918 hasConcept C185856081 @default.
• W4313312918 hasConcept C25498285 @default.
• W4313312918 hasConcept C2776914184 @default.
• W4313312918 hasConcept C2777107010 @default.
• W4313312918 hasConcept C2778334475 @default.
• W4313312918 hasConcept C2778790584 @default.
• W4313312918 hasConcept C2780775167 @default.
• W4313312918 hasConcept C28328180 @default.
• W4313312918 hasConcept C42219234 @default.
• W4313312918 hasConcept C71924100 @default.
• W4313312918 hasConcept C86803240 @default.
• W4313312918 hasConcept C87753298 @default.
• W4313312918 hasConcept C92020748 @default.
• W4313312918 hasConcept C95444343 @default.
• W4313312918 hasConcept C98274493 @default.
• W4313312918 hasConceptScore W4313312918C118552586 @default.
• W4313312918 hasConceptScore W4313312918C126322002 @default.
• W4313312918 hasConceptScore W4313312918C136834591 @default.
• W4313312918 hasConceptScore W4313312918C160539049 @default.
• W4313312918 hasConceptScore W4313312918C170493617 @default.

• next