Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313313050> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4313313050 endingPage "109604" @default.
- W4313313050 startingPage "109604" @default.
- W4313313050 abstract "Increasing evidence has noted that neuroinflammation contributes to the pathological processes of cognitive impairment of obstructive sleep apnea (OSA) patients. Interleukin (IL) -33/suppression of tumorigenicity 2 (ST2) signaling pathway plays well-defined roles in the inflammatory progression. The study aims to elucidate whether IL-33/ST2 signaling pathway plays a role in the cognitive dysfunction in patients with OSA via regulating neuroinflammation. We found that compared with control subjects, patients with OSA showed significantly elevated IL-33, ST2 and p65 nuclear factor-kappa B (NF-κB) levels in peripheral blood mononuclear cells (PBMCs) and inflammatory cytokines IL-6, IL-8 in serum, which were positively correlated with disease severity. Meanwhile, OSA patients exhibited a decline in Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores, suggesting mild cognitive impairment. Continuous positive airway pressure (CPAP) treatment for 12 weeks significantly decreased the expression of IL-33, ST2, p65NF-κB, IL-6 and IL-8, as well as improved cognitive function of OSA patients. Moreover, the IL-33/ST2 signaling was closely correlated with sleep respiratory parameters and cognitive dysfunction. To further explore the underlying mechanism of IL-33/ST2 signaling pathway, we stimulated human microglial clone 3 (HMC3) cells with lipopolysaccharide (LPS) to mimic neuroinflammatory response in vitro. The results showed that LPS treatment led to an increase in IL-33 and ST2 expression in a dose- dependent manner, along with an increased secretion of IL-6 and IL-8. Functional experiments showed that knockdown of IL-33 ameliorated LPS-induced neuroinflammation via suppressing NF-κB signaling. Overall, current findings suggest that IL-33/ST2 signaling participated in the cognitive impairment of OSA patients by promoting neuroinflammation via activating NF-κB signaling. These results may provide a novel therapeutic target for treating OSA- associated cognitive dysfunction." @default.
- W4313313050 created "2023-01-06" @default.
- W4313313050 creator A5000021360 @default.
- W4313313050 creator A5018055824 @default.
- W4313313050 creator A5054390607 @default.
- W4313313050 creator A5056552998 @default.
- W4313313050 creator A5063089557 @default.
- W4313313050 creator A5075597621 @default.
- W4313313050 date "2023-02-01" @default.
- W4313313050 modified "2023-10-09" @default.
- W4313313050 title "IL-33/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea" @default.
- W4313313050 cites W1968901258 @default.
- W4313313050 cites W2010036720 @default.
- W4313313050 cites W2025506526 @default.
- W4313313050 cites W2111885819 @default.
- W4313313050 cites W2135735522 @default.
- W4313313050 cites W2302301108 @default.
- W4313313050 cites W2521639562 @default.
- W4313313050 cites W2730034759 @default.
- W4313313050 cites W2751820267 @default.
- W4313313050 cites W2757670405 @default.
- W4313313050 cites W2809566874 @default.
- W4313313050 cites W2886309186 @default.
- W4313313050 cites W2911500694 @default.
- W4313313050 cites W2935954941 @default.
- W4313313050 cites W2959442417 @default.
- W4313313050 cites W2998858738 @default.
- W4313313050 cites W3016662816 @default.
- W4313313050 cites W3046892192 @default.
- W4313313050 cites W3085565225 @default.
- W4313313050 cites W3102151968 @default.
- W4313313050 cites W3167047370 @default.
- W4313313050 cites W3172053960 @default.
- W4313313050 cites W3176350800 @default.
- W4313313050 cites W3182293560 @default.
- W4313313050 cites W3187356885 @default.
- W4313313050 cites W3188027618 @default.
- W4313313050 cites W3196390997 @default.
- W4313313050 cites W3198477072 @default.
- W4313313050 cites W4306367183 @default.
- W4313313050 cites W4306662091 @default.
- W4313313050 doi "https://doi.org/10.1016/j.intimp.2022.109604" @default.
- W4313313050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36580760" @default.
- W4313313050 hasPublicationYear "2023" @default.
- W4313313050 type Work @default.
- W4313313050 citedByCount "2" @default.
- W4313313050 countsByYear W43133130502023 @default.
- W4313313050 crossrefType "journal-article" @default.
- W4313313050 hasAuthorship W4313313050A5000021360 @default.
- W4313313050 hasAuthorship W4313313050A5018055824 @default.
- W4313313050 hasAuthorship W4313313050A5054390607 @default.
- W4313313050 hasAuthorship W4313313050A5056552998 @default.
- W4313313050 hasAuthorship W4313313050A5063089557 @default.
- W4313313050 hasAuthorship W4313313050A5075597621 @default.
- W4313313050 hasConcept C126322002 @default.
- W4313313050 hasConcept C134018914 @default.
- W4313313050 hasConcept C164027704 @default.
- W4313313050 hasConcept C203014093 @default.
- W4313313050 hasConcept C2776006263 @default.
- W4313313050 hasConcept C2776252253 @default.
- W4313313050 hasConcept C2776914184 @default.
- W4313313050 hasConcept C2777935920 @default.
- W4313313050 hasConcept C2779547634 @default.
- W4313313050 hasConcept C71924100 @default.
- W4313313050 hasConcept C87753298 @default.
- W4313313050 hasConceptScore W4313313050C126322002 @default.
- W4313313050 hasConceptScore W4313313050C134018914 @default.
- W4313313050 hasConceptScore W4313313050C164027704 @default.
- W4313313050 hasConceptScore W4313313050C203014093 @default.
- W4313313050 hasConceptScore W4313313050C2776006263 @default.
- W4313313050 hasConceptScore W4313313050C2776252253 @default.
- W4313313050 hasConceptScore W4313313050C2776914184 @default.
- W4313313050 hasConceptScore W4313313050C2777935920 @default.
- W4313313050 hasConceptScore W4313313050C2779547634 @default.
- W4313313050 hasConceptScore W4313313050C71924100 @default.
- W4313313050 hasConceptScore W4313313050C87753298 @default.
- W4313313050 hasFunder F4320321001 @default.
- W4313313050 hasFunder F4320335789 @default.
- W4313313050 hasLocation W43133130501 @default.
- W4313313050 hasLocation W43133130502 @default.
- W4313313050 hasOpenAccess W4313313050 @default.
- W4313313050 hasPrimaryLocation W43133130501 @default.
- W4313313050 hasRelatedWork W2009334673 @default.
- W4313313050 hasRelatedWork W2077447344 @default.
- W4313313050 hasRelatedWork W2171331691 @default.
- W4313313050 hasRelatedWork W2313033156 @default.
- W4313313050 hasRelatedWork W2410202669 @default.
- W4313313050 hasRelatedWork W2735949591 @default.
- W4313313050 hasRelatedWork W2779616850 @default.
- W4313313050 hasRelatedWork W3131438189 @default.
- W4313313050 hasRelatedWork W4283030273 @default.
- W4313313050 hasRelatedWork W918923669 @default.
- W4313313050 hasVolume "115" @default.
- W4313313050 isParatext "false" @default.
- W4313313050 isRetracted "false" @default.
- W4313313050 workType "article" @default.