Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313313070> ?p ?o ?g. }
- W4313313070 endingPage "846" @default.
- W4313313070 startingPage "829" @default.
- W4313313070 abstract "Abstract Microglial necroptosis exacerbates neurodegenerative diseases, central nervous system (CNS) injury, and demonstrates a proinflammatory process, but its contribution to subarachnoid hemorrhage (SAH) is poorly characterized. BCL‐2 homologous antagonist‐killer protein (Bak1), a critical regulatory molecule of endogenous apoptosis, can be involved in the pathologic process of necroptosis by regulating mitochondrial permeability. In this study, we revealed microglia undergo necroptosis after SAH in vivo and vitro. Western blot revealed that Bak1 was elevated at 24 h after SAH. Knocked down of Bak1 by adeno‐associated virus attenuates microglial necroptosis, alleviates neuroinflammation, and improves neurologic function after SAH in mice. Furthermore, oxyhemoglobin (10 μM) induced necroptosis in BV2 microglia, increasing Bak1 expression and mediating proinflammatory phenotype transformation, exacerbating oxidative stress and neuroinflammation. Abrogating BV2 Bak1 could reduce necroptosis by down‐regulating the expression of phosphorylated pseudokinase mixed lineage kinase domain‐like protein (p‐MLKL), then down‐regulating proinflammatory phenotype gene expression. RNA‐Seq showed that disrupting BV2 Bak1 down‐regulates multiple immune and inflammatory pathways and ameliorates cell injury by elevating thrombospondin 1 (THBS1) expression. In summary, we identified a critical regulatory role for Bak1 in microglial necroptosis and neuroinflammation after SAH. Bak1 is expected to be a potential target for the treatment strategy of SAH. image" @default.
- W4313313070 created "2023-01-06" @default.
- W4313313070 creator A5011077758 @default.
- W4313313070 creator A5012940856 @default.
- W4313313070 creator A5050295259 @default.
- W4313313070 creator A5050648429 @default.
- W4313313070 creator A5057522797 @default.
- W4313313070 creator A5068790292 @default.
- W4313313070 creator A5076170910 @default.
- W4313313070 creator A5083182176 @default.
- W4313313070 creator A5085185712 @default.
- W4313313070 date "2023-01-07" @default.
- W4313313070 modified "2023-10-15" @default.
- W4313313070 title "Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage" @default.
- W4313313070 cites W1986568749 @default.
- W4313313070 cites W1999894742 @default.
- W4313313070 cites W2023122823 @default.
- W4313313070 cites W2028107828 @default.
- W4313313070 cites W2048766205 @default.
- W4313313070 cites W2067379222 @default.
- W4313313070 cites W2100904149 @default.
- W4313313070 cites W2101321540 @default.
- W4313313070 cites W2116858345 @default.
- W4313313070 cites W2141756194 @default.
- W4313313070 cites W2172390696 @default.
- W4313313070 cites W2231291760 @default.
- W4313313070 cites W2520731555 @default.
- W4313313070 cites W2552070561 @default.
- W4313313070 cites W2733853790 @default.
- W4313313070 cites W2741362367 @default.
- W4313313070 cites W2753642667 @default.
- W4313313070 cites W2788640168 @default.
- W4313313070 cites W2798168525 @default.
- W4313313070 cites W2802143204 @default.
- W4313313070 cites W2827119614 @default.
- W4313313070 cites W2885643008 @default.
- W4313313070 cites W2897133250 @default.
- W4313313070 cites W2900537803 @default.
- W4313313070 cites W2901410206 @default.
- W4313313070 cites W2902287405 @default.
- W4313313070 cites W2905737912 @default.
- W4313313070 cites W2910885285 @default.
- W4313313070 cites W2944269146 @default.
- W4313313070 cites W2948490412 @default.
- W4313313070 cites W2951344798 @default.
- W4313313070 cites W2966269595 @default.
- W4313313070 cites W2985902667 @default.
- W4313313070 cites W2991029655 @default.
- W4313313070 cites W3006376336 @default.
- W4313313070 cites W3016651431 @default.
- W4313313070 cites W3082314084 @default.
- W4313313070 cites W3093756484 @default.
- W4313313070 cites W3094788163 @default.
- W4313313070 cites W3126652531 @default.
- W4313313070 cites W3153727323 @default.
- W4313313070 cites W3175084030 @default.
- W4313313070 cites W4206090850 @default.
- W4313313070 cites W787451496 @default.
- W4313313070 cites W845792455 @default.
- W4313313070 doi "https://doi.org/10.1111/jnc.15751" @default.
- W4313313070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36583235" @default.
- W4313313070 hasPublicationYear "2023" @default.
- W4313313070 type Work @default.
- W4313313070 citedByCount "0" @default.
- W4313313070 crossrefType "journal-article" @default.
- W4313313070 hasAuthorship W4313313070A5011077758 @default.
- W4313313070 hasAuthorship W4313313070A5012940856 @default.
- W4313313070 hasAuthorship W4313313070A5050295259 @default.
- W4313313070 hasAuthorship W4313313070A5050648429 @default.
- W4313313070 hasAuthorship W4313313070A5057522797 @default.
- W4313313070 hasAuthorship W4313313070A5068790292 @default.
- W4313313070 hasAuthorship W4313313070A5076170910 @default.
- W4313313070 hasAuthorship W4313313070A5083182176 @default.
- W4313313070 hasAuthorship W4313313070A5085185712 @default.
- W4313313070 hasBestOaLocation W43133130702 @default.
- W4313313070 hasConcept C164027704 @default.
- W4313313070 hasConcept C190283241 @default.
- W4313313070 hasConcept C203014093 @default.
- W4313313070 hasConcept C2776914184 @default.
- W4313313070 hasConcept C2779830541 @default.
- W4313313070 hasConcept C31573885 @default.
- W4313313070 hasConcept C502942594 @default.
- W4313313070 hasConcept C55493867 @default.
- W4313313070 hasConcept C86803240 @default.
- W4313313070 hasConcept C87753298 @default.
- W4313313070 hasConcept C94030615 @default.
- W4313313070 hasConcept C95444343 @default.
- W4313313070 hasConceptScore W4313313070C164027704 @default.
- W4313313070 hasConceptScore W4313313070C190283241 @default.
- W4313313070 hasConceptScore W4313313070C203014093 @default.
- W4313313070 hasConceptScore W4313313070C2776914184 @default.
- W4313313070 hasConceptScore W4313313070C2779830541 @default.
- W4313313070 hasConceptScore W4313313070C31573885 @default.
- W4313313070 hasConceptScore W4313313070C502942594 @default.
- W4313313070 hasConceptScore W4313313070C55493867 @default.
- W4313313070 hasConceptScore W4313313070C86803240 @default.
- W4313313070 hasConceptScore W4313313070C87753298 @default.
- W4313313070 hasConceptScore W4313313070C94030615 @default.