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- W4313313403 abstract "Abstract Stimulation of human peripheral blood lymphocytes (PBL) with pokeweed mitogen (PWM) induced consistent increases of intracellular levels of cyclic AMP and cyclic GMP within 15 min. Increases of cyclic AMP were observed in both B and T lymphocyte populations, but increase of cyclic GMP was observed only in the B lymphocyte population. The addition of anti-µ antibody to B cells abolished PWM-induced increase of cyclic GMP without any effect on cyclic AMP response. Anti-δ antibody did not show any inhibitory or stimulatory effect on PWM-induced increase of cyclic GMP or cyclic AMP. Pretreatment of B cells with anti-µ antibody at 37°C for 1 hr inhibited PWM-induced increase of cyclic GMP, whereas pretreatment with anti-µ antibody at 4°C did not show any inhibitory effect on PWM-induced increase of cyclic GMP. The effect of anti-µ-pretreatment was reversible and pretreated cells were recovered from the inhibitory effect of anti-µ antibody after 36 hr culture." @default.
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- W4313313403 date "1978-11-01" @default.
- W4313313403 modified "2023-09-28" @default.
- W4313313403 title "<i>In Vitro</i> Immune Response of Human Peripheral Lymphocytes" @default.
- W4313313403 doi "https://doi.org/10.4049/jimmunol.121.5.2088" @default.
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