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- W4313315078 startingPage "1842" @default.
- W4313315078 abstract "Abstract In vitro human plasma cell generation induced by both T-dependent (PWM) and T-independent (NWSM) mitogens was found to be suppressed by peripheral blood lymphocytes preincubated with human aggregated IgG. T cells, but not B lymphocytes, were able to mediate the suppressive activity; since aggregated (Fab)′2 fragments were found unable to generate suppressor cells, it was concluded that the suppressor cell was a T lymphocyte bearing Fcγ receptors. These cells appeared to be largely radiosensitive. In most cases the proliferative responses remained unchanged. Since NWSM-induced activation is not dependent on the presence of T cells, these results show that, at least in this case, T cells exert their suppressor function directly on B lymphocytes. Whether PWM-induced B cell differentiation is suppressed by the same mechanism or/and by inactivation of T helper lymphocytes remains under investigation." @default.
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- W4313315078 date "1979-05-01" @default.
- W4313315078 modified "2023-10-18" @default.
- W4313315078 title "Human B Cell Differentiation" @default.
- W4313315078 doi "https://doi.org/10.4049/jimmunol.122.5.1842" @default.
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