FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313325040> ?p ?o ?g. }

• W4313325040 endingPage "101615" @default.
• W4313325040 startingPage "101615" @default.
• W4313325040 abstract "Altered epigenetic reprogramming and events contribute to breast cancer (Bca) progression and metastasis. How the epigenetic histone demethylases modulate breast cancer progression remains poorly defined. We aimed to elucidate the biological roles of KDM4A in driving Notch1 activation and Bca progression.The KDM4A expression in Bca specimens was analyzed using quantitative PCR and immunohistochemical assays. The biological roles of KDM4A were evaluated using wound-healing assays and an in vivo metastasis model. The Chromatin Immunoprecipitation (ChIP)-qPCR assay was used to determine the role of KDM4A in Notch1 regulation.Here, we screened that targeting KDM4A could induce notable cell growth suppression. KDM4A is required for the growth and progression of Bca cells. High KDM4A enhances tumor migration abilities and in vivo lung metastasis. Bioinformatic analysis suggested that KDM4A was highly expressed in tumors and high KDM4A correlates with poor survival outcomes. KDM4A activates Notch1 expressions via directly binding to the promoters and demethylating H3K9me3 modifications. KDM4A inhibition reduces expressions of a list of Notch1 downstream targets, and ectopic expressions of ICN1 could restore the corresponding levels. KDM4A relies on Notch1 signaling to maintain cell growth, migration and self-renewal capacities. Lastly, we divided a panel of cell lines into KDM4Ahigh and KDM4Alow groups. Targeting Notch1 using specific LY3039478 could efficiently suppress cell growth and colony formation abilities of KDM4Ahigh Bca.Taken together, KDM4A could drive Bca progression via triggering the activation of Notch1 pathway by decreasing H3K9me3 levels, highlighting a promising therapeutic target for Bca." @default.
• W4313325040 created "2023-01-06" @default.
• W4313325040 creator A5006019048 @default.
• W4313325040 creator A5011156931 @default.
• W4313325040 creator A5011397619 @default.
• W4313325040 creator A5017947172 @default.
• W4313325040 creator A5027835055 @default.
• W4313325040 creator A5063822183 @default.
• W4313325040 creator A5079876146 @default.
• W4313325040 creator A5083583029 @default.
• W4313325040 creator A5088154815 @default.
• W4313325040 date "2023-02-01" @default.
• W4313325040 modified "2023-09-25" @default.
• W4313325040 title "Epigenetic regulator KDM4A activates Notch1-NICD-dependent signaling to drive tumorigenesis and metastasis in breast cancer" @default.
• W4313325040 cites W1917948530 @default.
• W4313325040 cites W1983670899 @default.
• W4313325040 cites W2084885369 @default.
• W4313325040 cites W2117247812 @default.
• W4313325040 cites W2141414987 @default.
• W4313325040 cites W2747915828 @default.
• W4313325040 cites W2752714009 @default.
• W4313325040 cites W2795441251 @default.
• W4313325040 cites W2953849769 @default.
• W4313325040 cites W2989325555 @default.
• W4313325040 cites W2997492439 @default.
• W4313325040 cites W3009974692 @default.
• W4313325040 cites W3010323140 @default.
• W4313325040 cites W3014207387 @default.
• W4313325040 cites W3036089381 @default.
• W4313325040 cites W3081722047 @default.
• W4313325040 cites W3083153937 @default.
• W4313325040 cites W3084087505 @default.
• W4313325040 cites W3088473918 @default.
• W4313325040 cites W3089307373 @default.
• W4313325040 cites W3092561193 @default.
• W4313325040 cites W3097514211 @default.
• W4313325040 cites W3108630326 @default.
• W4313325040 cites W3119005666 @default.
• W4313325040 cites W3138977384 @default.
• W4313325040 cites W3163964295 @default.
• W4313325040 cites W3178800560 @default.
• W4313325040 cites W3179495039 @default.
• W4313325040 cites W3188699651 @default.
• W4313325040 cites W3200715289 @default.
• W4313325040 cites W3205773396 @default.
• W4313325040 cites W3210618099 @default.
• W4313325040 cites W3212209145 @default.
• W4313325040 cites W4200066800 @default.
• W4313325040 cites W4205101015 @default.
• W4313325040 cites W4205724345 @default.
• W4313325040 cites W4221062443 @default.
• W4313325040 cites W4225638463 @default.
• W4313325040 doi "https://doi.org/10.1016/j.tranon.2022.101615" @default.
• W4313325040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36592610" @default.
• W4313325040 hasPublicationYear "2023" @default.
• W4313325040 type Work @default.
• W4313325040 citedByCount "2" @default.
• W4313325040 countsByYear W43133250402023 @default.
• W4313325040 crossrefType "journal-article" @default.
• W4313325040 hasAuthorship W4313325040A5006019048 @default.
• W4313325040 hasAuthorship W4313325040A5011156931 @default.
• W4313325040 hasAuthorship W4313325040A5011397619 @default.
• W4313325040 hasAuthorship W4313325040A5017947172 @default.
• W4313325040 hasAuthorship W4313325040A5027835055 @default.
• W4313325040 hasAuthorship W4313325040A5063822183 @default.
• W4313325040 hasAuthorship W4313325040A5079876146 @default.
• W4313325040 hasAuthorship W4313325040A5083583029 @default.
• W4313325040 hasAuthorship W4313325040A5088154815 @default.
• W4313325040 hasBestOaLocation W43133250401 @default.
• W4313325040 hasConcept C101762097 @default.
• W4313325040 hasConcept C104317684 @default.
• W4313325040 hasConcept C121608353 @default.
• W4313325040 hasConcept C134320426 @default.
• W4313325040 hasConcept C150194340 @default.
• W4313325040 hasConcept C185592680 @default.
• W4313325040 hasConcept C2779013556 @default.
• W4313325040 hasConcept C2779256057 @default.
• W4313325040 hasConcept C41091548 @default.
• W4313325040 hasConcept C502942594 @default.
• W4313325040 hasConcept C54355233 @default.
• W4313325040 hasConcept C55493867 @default.
• W4313325040 hasConcept C555283112 @default.
• W4313325040 hasConcept C62112901 @default.
• W4313325040 hasConcept C86803240 @default.
• W4313325040 hasConcept C95444343 @default.
• W4313325040 hasConceptScore W4313325040C101762097 @default.
• W4313325040 hasConceptScore W4313325040C104317684 @default.
• W4313325040 hasConceptScore W4313325040C121608353 @default.
• W4313325040 hasConceptScore W4313325040C134320426 @default.
• W4313325040 hasConceptScore W4313325040C150194340 @default.
• W4313325040 hasConceptScore W4313325040C185592680 @default.
• W4313325040 hasConceptScore W4313325040C2779013556 @default.
• W4313325040 hasConceptScore W4313325040C2779256057 @default.
• W4313325040 hasConceptScore W4313325040C41091548 @default.
• W4313325040 hasConceptScore W4313325040C502942594 @default.
• W4313325040 hasConceptScore W4313325040C54355233 @default.
• W4313325040 hasConceptScore W4313325040C55493867 @default.
• W4313325040 hasConceptScore W4313325040C555283112 @default.

• next