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- W4313325066 endingPage "152321" @default.
- W4313325066 startingPage "152321" @default.
- W4313325066 abstract "Mycobacterium tuberculosis has thrived in parallel with humans for millennia, and despite our efforts, M. tuberculosis continues to plague us, currently infecting a third of the world’s population. The success of M. tuberculosis has recently been attributed, in part, to the PE-PPE family; a unique collection of 168 proteins fundamentally involved in the pathogenesis of M. tuberculosis. The PE-PPE family proteins have been at the forefront of intense research efforts since their discovery in 1998 and whilst our knowledge and understanding has significantly advanced over the last two decades, many important questions remain to be elucidated. This review consolidates and examines the vast body of existing literature regarding the PE-PPE family proteins, with respect to the latest developments in elucidating their evolution, structure, subcellular localisation, function, and immunogenicity. This review also highlights significant inconsistencies and contradictions within the field. Additionally, possible explanations for these knowledge gaps are explored. Lastly, this review poses many important questions, which need to be addressed to complete our understanding of the PE-PPE family, as well as highlighting the challenges associated with studying this enigmatic family of proteins. Further research into the PE-PPE family, together with technological advancements in genomics and proteomics, will undoubtedly improve our understanding of the pathogenesis of M. tuberculosis, as well as identify key targets/candidates for the development of novel drugs, diagnostics, and vaccines." @default.
- W4313325066 created "2023-01-06" @default.
- W4313325066 creator A5003836770 @default.
- W4313325066 creator A5062104862 @default.
- W4313325066 creator A5077178986 @default.
- W4313325066 date "2023-03-01" @default.
- W4313325066 modified "2023-09-30" @default.
- W4313325066 title "The PE-PPE Family of Mycobacterium tuberculosis: Proteins in Disguise" @default.
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