Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313330008> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4313330008 abstract "<p>Increased saturated fatty acid levels in membrane phospholipids have been implicated in the development of metabolic disease. Here, we tested the hypothesis that increased saturated fatty acid (SFA) content in cell membranes negatively impacts adipocyte insulin signaling. Pre-adipocyte cell models with elevated SFA levels in phospholipids were generated by disrupting the <em>ADIPOR2</em> locus, which resulted in a striking two-fold increase in SFA-containing phosphatidylcholines and phosphatidylethanolamines, which persisted in differentiated adipocytes. Similar changes in phospholipid composition were observed in white adipose tissues isolated from the ADIPOR2 knockout mice. The SFA levels in phospholipids could be further increased by treating <em>ADIPOR2</em>-deficient cells with palmitic acid and resulted in reduced membrane fluidity and endoplasmic reticulum stress in mouse and human pre-adipocytes. Strikingly, increased SFA levels in differentiated adipocyte phospholipids had no effect on adipocyte gene expression or insulin signaling <em>in vitro</em>. Similarly, increased adipocyte phospholipid saturation did not impair white adipose tissue function <em>in vivo</em>, even in mice fed a high saturated fat diet at thermoneutrality. We conclude that increasing SFA levels in adipocyte phospholipids is well tolerated and does not affect adipocyte insulin signaling <em>in vitro</em> and <em>in vivo</em>.</p>" @default.
- W4313330008 created "2023-01-06" @default.
- W4313330008 creator A5011756139 @default.
- W4313330008 creator A5012885402 @default.
- W4313330008 creator A5016064806 @default.
- W4313330008 creator A5016385816 @default.
- W4313330008 creator A5024366362 @default.
- W4313330008 creator A5026711091 @default.
- W4313330008 creator A5027598060 @default.
- W4313330008 creator A5028629304 @default.
- W4313330008 creator A5034670957 @default.
- W4313330008 creator A5035761279 @default.
- W4313330008 creator A5038296609 @default.
- W4313330008 creator A5041038982 @default.
- W4313330008 creator A5051621776 @default.
- W4313330008 creator A5051677373 @default.
- W4313330008 creator A5058873811 @default.
- W4313330008 creator A5067284329 @default.
- W4313330008 creator A5070282117 @default.
- W4313330008 creator A5072973682 @default.
- W4313330008 creator A5075072986 @default.
- W4313330008 creator A5080445805 @default.
- W4313330008 date "2022-12-29" @default.
- W4313330008 modified "2023-09-30" @default.
- W4313330008 title "ELEVATED ADIPOCYTE MEMBRANE PHOSPHOLIPID SATURATION DOES NOT COMPROMISE INSULIN SIGNALING" @default.
- W4313330008 doi "https://doi.org/10.2337/figshare.21782726.v1" @default.
- W4313330008 hasPublicationYear "2022" @default.
- W4313330008 type Work @default.
- W4313330008 citedByCount "0" @default.
- W4313330008 crossrefType "posted-content" @default.
- W4313330008 hasAuthorship W4313330008A5011756139 @default.
- W4313330008 hasAuthorship W4313330008A5012885402 @default.
- W4313330008 hasAuthorship W4313330008A5016064806 @default.
- W4313330008 hasAuthorship W4313330008A5016385816 @default.
- W4313330008 hasAuthorship W4313330008A5024366362 @default.
- W4313330008 hasAuthorship W4313330008A5026711091 @default.
- W4313330008 hasAuthorship W4313330008A5027598060 @default.
- W4313330008 hasAuthorship W4313330008A5028629304 @default.
- W4313330008 hasAuthorship W4313330008A5034670957 @default.
- W4313330008 hasAuthorship W4313330008A5035761279 @default.
- W4313330008 hasAuthorship W4313330008A5038296609 @default.
- W4313330008 hasAuthorship W4313330008A5041038982 @default.
- W4313330008 hasAuthorship W4313330008A5051621776 @default.
- W4313330008 hasAuthorship W4313330008A5051677373 @default.
- W4313330008 hasAuthorship W4313330008A5058873811 @default.
- W4313330008 hasAuthorship W4313330008A5067284329 @default.
- W4313330008 hasAuthorship W4313330008A5070282117 @default.
- W4313330008 hasAuthorship W4313330008A5072973682 @default.
- W4313330008 hasAuthorship W4313330008A5075072986 @default.
- W4313330008 hasAuthorship W4313330008A5080445805 @default.
- W4313330008 hasBestOaLocation W43133300081 @default.
- W4313330008 hasConcept C126322002 @default.
- W4313330008 hasConcept C134018914 @default.
- W4313330008 hasConcept C151955695 @default.
- W4313330008 hasConcept C171089720 @default.
- W4313330008 hasConcept C185592680 @default.
- W4313330008 hasConcept C2776175234 @default.
- W4313330008 hasConcept C2778918659 @default.
- W4313330008 hasConcept C41625074 @default.
- W4313330008 hasConcept C55493867 @default.
- W4313330008 hasConcept C71924100 @default.
- W4313330008 hasConcept C86803240 @default.
- W4313330008 hasConceptScore W4313330008C126322002 @default.
- W4313330008 hasConceptScore W4313330008C134018914 @default.
- W4313330008 hasConceptScore W4313330008C151955695 @default.
- W4313330008 hasConceptScore W4313330008C171089720 @default.
- W4313330008 hasConceptScore W4313330008C185592680 @default.
- W4313330008 hasConceptScore W4313330008C2776175234 @default.
- W4313330008 hasConceptScore W4313330008C2778918659 @default.
- W4313330008 hasConceptScore W4313330008C41625074 @default.
- W4313330008 hasConceptScore W4313330008C55493867 @default.
- W4313330008 hasConceptScore W4313330008C71924100 @default.
- W4313330008 hasConceptScore W4313330008C86803240 @default.
- W4313330008 hasLocation W43133300081 @default.
- W4313330008 hasOpenAccess W4313330008 @default.
- W4313330008 hasPrimaryLocation W43133300081 @default.
- W4313330008 hasRelatedWork W1957106181 @default.
- W4313330008 hasRelatedWork W1965568810 @default.
- W4313330008 hasRelatedWork W2025731911 @default.
- W4313330008 hasRelatedWork W2027098794 @default.
- W4313330008 hasRelatedWork W2036460863 @default.
- W4313330008 hasRelatedWork W2125103862 @default.
- W4313330008 hasRelatedWork W2142749562 @default.
- W4313330008 hasRelatedWork W2228231544 @default.
- W4313330008 hasRelatedWork W4242900151 @default.
- W4313330008 hasRelatedWork W4253482381 @default.
- W4313330008 isParatext "false" @default.
- W4313330008 isRetracted "false" @default.
- W4313330008 workType "article" @default.