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- W4313330051 abstract "Abstract The song control nucleus HVC of songbirds has emerged as a widespread model system to study adult neurogenesis and the factors that modulate the incorporation of new neurons, including seasonal state, sex differences or sex steroid hormone concentrations. However, the specific function of these new neurons born in adulthood remains poorly understood. We implemented a new procedure based on focal X-ray irradiation to deplete neural progenitors in the ventricular zone adjacent to HVC and study the functional consequences. A 23 Gy dose depleted by more than 50 percent the incorporation of BrdU in neural progenitors, a depletion that was confirmed by a significant decrease in doublecortin positive neurons. This depletion of neurogenesis significantly increased the variability of testosterone-induced songs in females and decreased their bandwidth. Expression of the immediate early gene ZENK (a.k.a. egr-1) in secondary auditory areas of the telencephalon that respond to song was also inhibited. These data provide compelling evidence that new neurons in HVC play a role in both song production and perception and that X-ray focal irradiation represents an excellent tool to advance our understanding of adult neurogenesis." @default.
- W4313330051 created "2023-01-06" @default.
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- W4313330051 date "2022-12-29" @default.
- W4313330051 modified "2023-09-30" @default.
- W4313330051 title "Ablation of neural progenitors by focal X-ray irradiation: effects on song production and perception in canaries" @default.
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- W4313330051 doi "https://doi.org/10.21203/rs.3.rs-2402033/v1" @default.
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