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- W4313330130 abstract "Abstract Alzheimer's disease (AD) is associated with mitochondrial dysfunction and disturbances in neurotransmitter systems. Depression is a common comorbidity of AD, and the disruption of monoaminergic neurotransmission may be involved in the pathophysiology of AD. Assessment of mitochondrial dysfunction was performed by measuring mitochondrial respiratory rate; changes in monoamine neurotransmission were evaluated by measuring mitochondrial monoamine oxidase B (MAO-B) activity and serotonin transporter (SERT) activity in platelets. The decreases in the maximum capacity of the electron transport system and a decrease in the respiratory reserve capacity compared to controls was significant in intact platelets of AD patients but not in vascular dementia (VD) patients, indicating some specificity of these biomarkers for AD. In permeabilized platelets, parameters of mitochondrial respiration were not significantly altered in AD, suggesting that the reduction observed in intact platelets may be due to impaired availability of respiratory chain enzyme substrates. MAO-B activity and SERT activity were not significantly different between controls and AD and VD patients. The association of biochemical parameters with cognitive decline and comorbid depression in subjects with AD and VD showed the applicability of mitochondrial respiration in intact platelets, but not MAO-B activity and SERT activity, as a blood biomarker of AD." @default.
- W4313330130 created "2023-01-06" @default.
- W4313330130 creator A5008926112 @default.
- W4313330130 creator A5011215655 @default.
- W4313330130 creator A5012649852 @default.
- W4313330130 creator A5015501358 @default.
- W4313330130 creator A5017759516 @default.
- W4313330130 creator A5048556065 @default.
- W4313330130 date "2022-12-29" @default.
- W4313330130 modified "2023-10-17" @default.
- W4313330130 title "Disruption of mitochondrial respiration and the monoamine neurotransmitter system in Alzheimer's disease" @default.
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