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- W4313331188 abstract "Abstract Previously, we analyzed the proximal IL-4 promoter in directing Th2-specific activity. An 800-base pair proximal promoter conferred some Th2-selective expression in transgenic mice. However, this region directed extremely low reporter mRNA levels relative to endogenous IL-4 mRNA, suggesting that full gene activity requires additional enhancer elements. Here, we analyzed large genomic IL-4 regions for enhancer activity and interaction with transcription factors. The proximal IL-4 promoter is only moderately augmented by GATA-3, but certain genomic regions significantly enhanced GATA-3 promoter transactivation. Some enhancing regions contained consensus GATA sites that bound Th2-specific complexes. However, retroviral transduction of GATA-3 into developing T cells induced IL-5 to full Th2 levels, but only partially restored IL-4 production. Thus, we propose that GATA-3 is permissive, but not sufficient, for full IL-4 enhancement and may act through GATA elements surrounding the IL-13/IL-4 gene locus." @default.
- W4313331188 created "2023-01-06" @default.
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- W4313331188 date "1998-10-15" @default.
- W4313331188 modified "2023-10-16" @default.
- W4313331188 title "Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation" @default.
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- W4313331188 doi "https://doi.org/10.4049/jimmunol.161.8.3822" @default.
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