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- W4313331218 abstract "Abstract Purpose We aimed to determine if Trisomy 21 (T21) affected gastrointestinal outcomes for children with duodenal atresia (DA). Methods We identified children born with DA between 1991-2017. Cases were divided into DA with T21 and DA without T21. Ten healthy controls per case were included . Esophageal, ulcerative, obstructive and stomach complaints were assessed. Risk ratios (RR), rate ratios (RaR) and Cox models were constructed. Analyses were performed for cases versus controls, and for T21 cases versus non-T21 cases. Results DA cases totaled 52: 22 had T21 and 30 did not. There were 520 controls. DA cases had more gastrointestinal complaints than controls. T21 cases were at greater risk and frequency of esophageal disease than non-T21 cases (RR=4.08, p=0.002, RaR=69.8, p<0.001). T21 and non-T21 cases were equally likely to present with obstruction (RR=0.91, p=1), but T21 cases complained of obstructive symptoms less (RaR=0.57, p=0.003). T21 and non-T21 cases had the same risk of stomach diseases, but T21 cases complained more frequently (RaR=6.20, p<0.001). Cox models supported these observations. T21 did not affect ulcerative diseases. Conclusion DA cases had more gastrointestinal problems than controls. T21 increased esophageal and gastric complaints in DA cases but did not affect ulcerative and obstructive complaints." @default.
- W4313331218 created "2023-01-06" @default.
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- W4313331218 date "2022-12-29" @default.
- W4313331218 modified "2023-09-30" @default.
- W4313331218 title "Effect of Trisomy 21 on Long-term Gastrointestinal Outcomes in Duodenal Atresia" @default.
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- W4313331218 doi "https://doi.org/10.21203/rs.3.rs-2406607/v1" @default.
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