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- W4313331319 endingPage "1177" @default.
- W4313331319 startingPage "1171" @default.
- W4313331319 abstract "Abstract The activation of CD4+ T lymphocytes upon Ag stimulation plays a critical role in adverse immune responses including drug-specific hypersensitivity reactions. We examined the modulation of T cell phenotype induced by hapten-specific stimulation using the model of β-lactam antibiotics such as penicillin G (Pen G), Pen V, and ampicillin (Amp). When PBMC of donors suffering from hypersensitivity reactions against β-lactams were stimulated in vitro with different doses of Pen G, a preferential expansion of IL-4-producing TCRαβ+ cells was detected. A panel of T cell clones was then prepared from Pen G-specific lines after two cycles of restimulation with the hapten. For the majority of these clones, we found that high doses of Pen G induced optimal IL-4 secretion, whereas the amount of IFN-γ secreted was inversely correlated with the dose of Pen G, thus leading to a hapten-inducible shift of the fuctional phenotypes for some of the clones. Finally, Pen V and Amp were used to modulate different Ag-induced immune responses. We found that Amp had no influence on the cytokine pattern induced by specific Ag or mitogens. In contrast, Pen V inhibited the secretion of IFN-γ, but not IL-4, most likely by Ag-independent mechanisms. This last finding may open new applications for immune intervention in those diseases in which polarized Th1 responses are involved in the development of the pathology." @default.
- W4313331319 created "2023-01-06" @default.
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- W4313331319 date "1999-01-15" @default.
- W4313331319 modified "2023-10-04" @default.
- W4313331319 title "Antigen-Dependent and -Independent IFN-γ Modulation by Penicillins" @default.
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- W4313331319 doi "https://doi.org/10.4049/jimmunol.162.2.1171" @default.
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