Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313331400> ?p ?o ?g. }
- W4313331400 endingPage "5312" @default.
- W4313331400 startingPage "5303" @default.
- W4313331400 abstract "Abstract Oral tolerance was induced in BALB/c mice by feeding low dose β2-glycoprotein I (β2GPI). The β2GPI-fed mice did not develop serologic and clinical markers of experimental antiphospholipid syndrome (APS) upon immunization with the autoantigen. The treated group was characterized by low titers of serum anti-β2GPI and anticardiolipin Abs in the serum, lack of fetal resorptions, low incidence of thrombocytopenia, and normal aPTT (activated partial thromboplastin time) values. β2GPI given orally before priming with β2GPI resulted in complete prevention of experimental APS development; β2GPI given at an early stage of the disease reduced clinical manifestations. However, administration of β2GPI 70 days postimmunization had a less significant effect on disease expression. Tolerized mice exhibited a diminished T lymphocyte proliferation response to β2GPI in comparison with β2GPI-immunized mice fed with OVA. When nontolerant β2GPI-primed T lymphocytes were mixed with T lymphocytes derived from tolerized mice, a significant inhibition of proliferation upon exposure to β2GPI was observed. The induction of suppression was β2GPI specific and driven, as well as TGF-β mediated. The β2GPI-specific response of T lymphocytes from the β2GPI-fed mice was reversed by anti-TGF-β Abs. The tolerance was adoptively transferred by CD8+ T cells from the tolerized mice into naive mice. Those CD8+ cells were MHC class I restricted, found to secrete TGF-β, and had no cytolytic activity. Oral administration of β2GPI suppressed priming of CTLs in the recipient mice. In sum, β2GPI-induced oral tolerance has an immunomodulatory effect in experimental APS, demonstrating the importance of β2GPI in the pathogenesis of the disease." @default.
- W4313331400 created "2023-01-06" @default.
- W4313331400 creator A5031694589 @default.
- W4313331400 creator A5053803963 @default.
- W4313331400 creator A5074738902 @default.
- W4313331400 creator A5075106701 @default.
- W4313331400 creator A5079447134 @default.
- W4313331400 creator A5088694640 @default.
- W4313331400 date "1998-11-15" @default.
- W4313331400 modified "2023-10-17" @default.
- W4313331400 title "Oral Tolerance to Low Dose β2-Glycoprotein I: Immunomodulation of Experimental Antiphospholipid Syndrome" @default.
- W4313331400 cites W1500134182 @default.
- W4313331400 cites W1529826315 @default.
- W4313331400 cites W1531017810 @default.
- W4313331400 cites W1546377462 @default.
- W4313331400 cites W1560656231 @default.
- W4313331400 cites W1579431146 @default.
- W4313331400 cites W1589746940 @default.
- W4313331400 cites W1627534535 @default.
- W4313331400 cites W1905494569 @default.
- W4313331400 cites W1963499632 @default.
- W4313331400 cites W1968274103 @default.
- W4313331400 cites W1969370052 @default.
- W4313331400 cites W1973838240 @default.
- W4313331400 cites W1984636261 @default.
- W4313331400 cites W1988317772 @default.
- W4313331400 cites W2000055469 @default.
- W4313331400 cites W2002003044 @default.
- W4313331400 cites W2007245529 @default.
- W4313331400 cites W2018948925 @default.
- W4313331400 cites W2020317622 @default.
- W4313331400 cites W2023052741 @default.
- W4313331400 cites W2025329539 @default.
- W4313331400 cites W2034249407 @default.
- W4313331400 cites W2047906671 @default.
- W4313331400 cites W2067632818 @default.
- W4313331400 cites W2069448335 @default.
- W4313331400 cites W2074061180 @default.
- W4313331400 cites W2075376701 @default.
- W4313331400 cites W2081062408 @default.
- W4313331400 cites W2097994780 @default.
- W4313331400 cites W2099836298 @default.
- W4313331400 cites W2104964332 @default.
- W4313331400 cites W2107307935 @default.
- W4313331400 cites W2113891001 @default.
- W4313331400 cites W2118857294 @default.
- W4313331400 cites W2126775039 @default.
- W4313331400 cites W2128707261 @default.
- W4313331400 cites W2156471525 @default.
- W4313331400 cites W2163682172 @default.
- W4313331400 cites W2209800418 @default.
- W4313331400 cites W2321042109 @default.
- W4313331400 cites W2414534066 @default.
- W4313331400 cites W2500365135 @default.
- W4313331400 cites W4247854147 @default.
- W4313331400 cites W48454663 @default.
- W4313331400 doi "https://doi.org/10.4049/jimmunol.161.10.5303" @default.
- W4313331400 hasPublicationYear "1998" @default.
- W4313331400 type Work @default.
- W4313331400 citedByCount "22" @default.
- W4313331400 countsByYear W43133314002014 @default.
- W4313331400 countsByYear W43133314002015 @default.
- W4313331400 countsByYear W43133314002018 @default.
- W4313331400 countsByYear W43133314002019 @default.
- W4313331400 countsByYear W43133314002022 @default.
- W4313331400 crossrefType "journal-article" @default.
- W4313331400 hasAuthorship W4313331400A5031694589 @default.
- W4313331400 hasAuthorship W4313331400A5053803963 @default.
- W4313331400 hasAuthorship W4313331400A5074738902 @default.
- W4313331400 hasAuthorship W4313331400A5075106701 @default.
- W4313331400 hasAuthorship W4313331400A5079447134 @default.
- W4313331400 hasAuthorship W4313331400A5088694640 @default.
- W4313331400 hasBestOaLocation W43133314001 @default.
- W4313331400 hasConcept C100701293 @default.
- W4313331400 hasConcept C126322002 @default.
- W4313331400 hasConcept C144594695 @default.
- W4313331400 hasConcept C147483822 @default.
- W4313331400 hasConcept C159654299 @default.
- W4313331400 hasConcept C167672396 @default.
- W4313331400 hasConcept C203014093 @default.
- W4313331400 hasConcept C2776874634 @default.
- W4313331400 hasConcept C2777016536 @default.
- W4313331400 hasConcept C2777702733 @default.
- W4313331400 hasConcept C2778382381 @default.
- W4313331400 hasConcept C59822182 @default.
- W4313331400 hasConcept C71924100 @default.
- W4313331400 hasConcept C81444415 @default.
- W4313331400 hasConcept C86803240 @default.
- W4313331400 hasConceptScore W4313331400C100701293 @default.
- W4313331400 hasConceptScore W4313331400C126322002 @default.
- W4313331400 hasConceptScore W4313331400C144594695 @default.
- W4313331400 hasConceptScore W4313331400C147483822 @default.
- W4313331400 hasConceptScore W4313331400C159654299 @default.
- W4313331400 hasConceptScore W4313331400C167672396 @default.
- W4313331400 hasConceptScore W4313331400C203014093 @default.
- W4313331400 hasConceptScore W4313331400C2776874634 @default.
- W4313331400 hasConceptScore W4313331400C2777016536 @default.
- W4313331400 hasConceptScore W4313331400C2777702733 @default.