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- W4313331433 abstract "At present, the chemical compositions of plant raw materials for the content of diterpenoid alkaloids have been studied in world research centers in various countries, their pharmacological and toxicological properties have been determined, and technological studies have been carried out in the field of obtaining them in production. At the Institute of Chemistry of Plant Substances, research on the study of diterpenoid alkaloids of plants of the genus Aconite, in particular, research to establish their chemical structure, biosynthesis, pharmacological and toxicological properties of diterpenoid alkaloids, and their production technology.
 Increasing requirements for the safety, efficacy, and quality of medicines necessitate the development of new and improvement of existing methods for their analysis. As a rule, the quality of substances is ensured by a set of analytical methods that allow confirming their authenticity, and determining the purity and quantitative content of the active substance. The methods and techniques used for this need to be constantly improved. Considering the above, the problem of the comparative study of physicochemical methods used for the analysis of substances is topical. The object of the study was the substance Antiarrhythmin. A new method for the qualitative and quantitative determination of N-deacetyllappaconitine hydrobromide in Antiarrhythmin substances has been developed. A comparative analysis of the spectrophotometers and the HPLC method was carried out.
 The HPLC method in isocratic mode is used for the sensitive determination of the quantitative analysis of Antiarrhythmin. This technique is simple and well reproduced. The validation results showed that the method has good linearity and within-laboratory precision. The developed method can be used for the determination of N-dezacetyllappaconitine hydrobromide in a substance during quality control." @default.
- W4313331433 created "2023-01-06" @default.
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- W4313331433 date "2022-12-15" @default.
- W4313331433 modified "2023-10-18" @default.
- W4313331433 title "DEVELOPMENT OF A METHOD FOR THE QUANTITATIVE DETERMINATION OF N-DEZACETYLAPPACONITINE HYDROBROMIDE IN THE DRUG OF THE ANTIARRHYTHMINE BY THE METHOD OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY AND ITS CHROMATOGRAPHIC BEHAVIOR" @default.
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- W4313331433 doi "https://doi.org/10.14258/jcprm.20220411308" @default.
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