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- W4313331452 startingPage "4476" @default.
- W4313331452 abstract "Abstract The potent accessory properties of dendritic cells (DC) develop sequentially during a process termed “maturation.” Splenic DC undergo functional maturation in vivo in response to the bacterial product LPS and migrate from the marginal zone to the T cell areas. The redistribution of fully mature DC, which present Ags encountered in the periphery, in the T cell area is likely to result in T cell priming. Unexpectedly, we found that DC rapidly die by apoptosis once they have entered the T cell zone. Injection of OVA peptide in OVA-specific, TCR-transgenic mice strongly delays the LPS-induced apoptosis of DC in situ. We conclude that mature DC are programmed to die unless they receive a survival signal from T cells and that the regulation of DC survival may be a mechanism aimed at controlling the initiation and the termination of the immune response." @default.
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- W4313331452 date "1998-11-01" @default.
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- W4313331452 title "Cutting Edge: Antigen-Specific T Lymphocytes Regulate Lipopolysaccharide-Induced Apoptosis of Dendritic Cells In Vivo" @default.
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- W4313331452 doi "https://doi.org/10.4049/jimmunol.161.9.4476" @default.
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