Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313331457> ?p ?o ?g. }
- W4313331457 endingPage "5672" @default.
- W4313331457 startingPage "5663" @default.
- W4313331457 abstract "Abstract By virtue of their target cell specificity, chemokines have the potential to selectively recruit leukocyte subpopulations into sites of inflammation. Their role in regulation of T lymphocyte traffic into lymph nodes during the development of an immune response has not previously been explored. The sensitization phase of contact hypersensitivity induced by the hapten, dinitrofluorobenzene (DNFB) in the mouse was used as a model of T lymphocyte trafficking in response to antigenic stimulation. Rapid accumulation of CD8+ and CD4+ T cells in the draining lymph nodes was closely associated with strongly enhanced expression of macrophage inflammatory protein (MIP)-1α and MIP-1β mRNAs and proteins. Mast cells accumulating in the nodes during DNFB sensitization were the predominant source of MIP-1β, whereas MIP-1α was expressed by multiple cell types. Neutralization of these chemokines profoundly inhibited T lymphocyte trafficking into lymph nodes and altered the outcome of a subsequent challenge to DNFB. Thus, β-chemokines regulate T lymphocyte emigration from the circulation into lymph nodes during an immune response and contribute significantly to the immunologic outcome." @default.
- W4313331457 created "2023-01-06" @default.
- W4313331457 creator A5004304607 @default.
- W4313331457 creator A5008430720 @default.
- W4313331457 creator A5024200175 @default.
- W4313331457 creator A5030797368 @default.
- W4313331457 creator A5034321862 @default.
- W4313331457 creator A5056117004 @default.
- W4313331457 creator A5067395273 @default.
- W4313331457 date "1998-11-15" @default.
- W4313331457 modified "2023-10-10" @default.
- W4313331457 title "Regulation of T Lymphocyte Trafficking into Lymph Nodes During an Immune Response by the Chemokines Macrophage Inflammatory Protein (MIP)-1α and MIP-1β" @default.
- W4313331457 cites W1549296148 @default.
- W4313331457 cites W1566990974 @default.
- W4313331457 cites W1578242760 @default.
- W4313331457 cites W1605861898 @default.
- W4313331457 cites W1664757944 @default.
- W4313331457 cites W1671259416 @default.
- W4313331457 cites W1849720919 @default.
- W4313331457 cites W1909819148 @default.
- W4313331457 cites W1925204255 @default.
- W4313331457 cites W1971505103 @default.
- W4313331457 cites W1981769649 @default.
- W4313331457 cites W1984123968 @default.
- W4313331457 cites W1999023229 @default.
- W4313331457 cites W2001309404 @default.
- W4313331457 cites W2019941955 @default.
- W4313331457 cites W2020455973 @default.
- W4313331457 cites W2031311732 @default.
- W4313331457 cites W2031488553 @default.
- W4313331457 cites W2032494769 @default.
- W4313331457 cites W2041062576 @default.
- W4313331457 cites W2047297797 @default.
- W4313331457 cites W2050329759 @default.
- W4313331457 cites W2053315646 @default.
- W4313331457 cites W2060338116 @default.
- W4313331457 cites W2061140050 @default.
- W4313331457 cites W2064267013 @default.
- W4313331457 cites W2075939418 @default.
- W4313331457 cites W2080780289 @default.
- W4313331457 cites W2098518381 @default.
- W4313331457 cites W2099388162 @default.
- W4313331457 cites W2102291237 @default.
- W4313331457 cites W2103493503 @default.
- W4313331457 cites W2105764600 @default.
- W4313331457 cites W2107469531 @default.
- W4313331457 cites W2115395126 @default.
- W4313331457 cites W2119741323 @default.
- W4313331457 cites W2124387157 @default.
- W4313331457 cites W2127921247 @default.
- W4313331457 cites W2128593833 @default.
- W4313331457 cites W2132505722 @default.
- W4313331457 cites W2133513836 @default.
- W4313331457 cites W2136059362 @default.
- W4313331457 cites W2136813292 @default.
- W4313331457 cites W2141924291 @default.
- W4313331457 cites W2146717075 @default.
- W4313331457 cites W2157021835 @default.
- W4313331457 cites W2161597539 @default.
- W4313331457 cites W2315695983 @default.
- W4313331457 doi "https://doi.org/10.4049/jimmunol.161.10.5663" @default.
- W4313331457 hasPublicationYear "1998" @default.
- W4313331457 type Work @default.
- W4313331457 citedByCount "52" @default.
- W4313331457 countsByYear W43133314572012 @default.
- W4313331457 countsByYear W43133314572013 @default.
- W4313331457 countsByYear W43133314572014 @default.
- W4313331457 countsByYear W43133314572016 @default.
- W4313331457 countsByYear W43133314572017 @default.
- W4313331457 countsByYear W43133314572019 @default.
- W4313331457 countsByYear W43133314572021 @default.
- W4313331457 crossrefType "journal-article" @default.
- W4313331457 hasAuthorship W4313331457A5004304607 @default.
- W4313331457 hasAuthorship W4313331457A5008430720 @default.
- W4313331457 hasAuthorship W4313331457A5024200175 @default.
- W4313331457 hasAuthorship W4313331457A5030797368 @default.
- W4313331457 hasAuthorship W4313331457A5034321862 @default.
- W4313331457 hasAuthorship W4313331457A5056117004 @default.
- W4313331457 hasAuthorship W4313331457A5067395273 @default.
- W4313331457 hasBestOaLocation W43133314571 @default.
- W4313331457 hasConcept C13373296 @default.
- W4313331457 hasConcept C142724271 @default.
- W4313331457 hasConcept C154317977 @default.
- W4313331457 hasConcept C167672396 @default.
- W4313331457 hasConcept C170217031 @default.
- W4313331457 hasConcept C202751555 @default.
- W4313331457 hasConcept C203014093 @default.
- W4313331457 hasConcept C2776217527 @default.
- W4313331457 hasConcept C2776914184 @default.
- W4313331457 hasConcept C2777761686 @default.
- W4313331457 hasConcept C2779720271 @default.
- W4313331457 hasConcept C55493867 @default.
- W4313331457 hasConcept C71924100 @default.
- W4313331457 hasConcept C86803240 @default.
- W4313331457 hasConcept C8891405 @default.
- W4313331457 hasConceptScore W4313331457C13373296 @default.
- W4313331457 hasConceptScore W4313331457C142724271 @default.
- W4313331457 hasConceptScore W4313331457C154317977 @default.