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• W4313331468 endingPage "5606" @default.
• W4313331468 startingPage "5600" @default.
• W4313331468 abstract "Abstract NK cells are believed to play a mandatory role during the early phases of Listeria monocytogenes infection by producing IFN-γ, which is required for the activation of macrophage effector functions. Mice deficient in the common cytokine receptor γ-chain (γc−/−), which completely lack NK cells, were used to examine whether NK cells were essential for resistance to Listeria infection in vivo. Surprisingly, infected γc−/− mice showed normal innate immunity and macrophage responses against sublethal Listeria infection 2 days postinfection. At this time point, γc−/− mice showed increased blood IFN-γ levels compared with those in noninfected controls, demonstrating an NK-independent source of IFN-γ, which explains early resistance. Listeria-infected γc−/− × recombinase-activating gene-2−/− double-deficient mice were unable to produce IFN-γ and were highly susceptible to L. monocytogenes. Since T cells, but not B cells, are major IFN-γ producers, and γc−/− T cells were found to be efficient IFN-γ producers in vitro, we conclude from these results that T cells functionally replace NK cells for the early IFN-γ production that is necessary for activating the innate immune system following infection with L. monocytogenes. This novel observation in listeriosis underscores how the adaptive immune response can maintain and influence innate immunity." @default.
• W4313331468 created "2023-01-06" @default.
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• W4313331468 date "1998-11-15" @default.
• W4313331468 modified "2023-10-14" @default.
• W4313331468 title "Early IFN-γ Production and Innate Immunity During<i>Listeria monocytogenes</i>Infection in the Absence of NK Cells" @default.
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• W4313331468 doi "https://doi.org/10.4049/jimmunol.161.10.5600" @default.
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