FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313331521> ?p ?o ?g. }

• W4313331521 endingPage "5563" @default.
• W4313331521 startingPage "5555" @default.
• W4313331521 abstract "Abstract Cbl-Crkl and Crkl-C3G interactions have been implicated in T cell and B cell receptor signaling and in the regulation of the small GTPase, Rap1. Recent evidence suggests that Rap1 plays a prominent role in the regulation of immunoreceptor tyrosine-based activation motif (ITAM) signaling. To gain insight into the role of Crkl in myeloid ITAM signaling, we investigated Cbl-Crkl and Crkl-C3G interactions following FcγRI aggregation in U937IF cells. FcγRI cross-linking of U937IF cells results in the tyrosine phosphorylation of Cbl, Crkl, and Hef-1, an increase in the association of Crkl with Cbl via direct SH2 domain interaction and increased Crkl-Hef-1 binding. Crkl constitutively binds to the guanine nucleotide-releasing protein, C3G, via direct SH3 domain binding. Our data show that distinct Cbl-Crkl and Crkl-C3G complexes exist in myeloid cells, suggesting that these complexes may modulate distinct signaling events. Anti-Crkl immunoprecipitations demonstrate that the ITAM-containing γ subunit of FcγRI is induced to form a complex with the Crkl protein, and Crkl binds to the cytoskeletal protein, Hef-1. The induced association of Crkl with Cbl, Hef-1, and FcγRIγ after FcγRI activation and the constitutive association between C3G and Crkl provide the first evidence that a FcγRIγ-Crkl-C3G complex may link ITAM receptors to the activation of Rap1 in myeloid cells." @default.
• W4313331521 created "2023-01-06" @default.
• W4313331521 creator A5015560149 @default.
• W4313331521 creator A5025976004 @default.
• W4313331521 creator A5027241068 @default.
• W4313331521 creator A5037565260 @default.
• W4313331521 creator A5060051979 @default.
• W4313331521 creator A5077589394 @default.
• W4313331521 creator A5091287803 @default.
• W4313331521 date "1998-11-15" @default.
• W4313331521 modified "2023-10-16" @default.
• W4313331521 title "Differential Interaction of Crkl with Cbl or C3G, Hef-1, and γ Subunit Immunoreceptor Tyrosine-Based Activation Motif in Signaling of Myeloid High Affinity Fc Receptor for IgG (FcγRI)" @default.
• W4313331521 cites W1478051885 @default.
• W4313331521 cites W1510108058 @default.
• W4313331521 cites W1533457677 @default.
• W4313331521 cites W1562828870 @default.
• W4313331521 cites W1590860783 @default.
• W4313331521 cites W1593363276 @default.
• W4313331521 cites W1595795928 @default.
• W4313331521 cites W1618519163 @default.
• W4313331521 cites W1623683757 @default.
• W4313331521 cites W1693793742 @default.
• W4313331521 cites W1965208564 @default.
• W4313331521 cites W1973755084 @default.
• W4313331521 cites W1978981774 @default.
• W4313331521 cites W1981096579 @default.
• W4313331521 cites W1988895001 @default.
• W4313331521 cites W1991378757 @default.
• W4313331521 cites W1999343583 @default.
• W4313331521 cites W2000182583 @default.
• W4313331521 cites W2004202136 @default.
• W4313331521 cites W2005581728 @default.
• W4313331521 cites W2005883617 @default.
• W4313331521 cites W2009082398 @default.
• W4313331521 cites W2010001433 @default.
• W4313331521 cites W2012177306 @default.
• W4313331521 cites W2012919908 @default.
• W4313331521 cites W2013452351 @default.
• W4313331521 cites W2020486839 @default.
• W4313331521 cites W2022395175 @default.
• W4313331521 cites W2030437907 @default.
• W4313331521 cites W2047743989 @default.
• W4313331521 cites W2052272939 @default.
• W4313331521 cites W2061895065 @default.
• W4313331521 cites W2062494005 @default.
• W4313331521 cites W2067415612 @default.
• W4313331521 cites W2100740895 @default.
• W4313331521 cites W2100877501 @default.
• W4313331521 cites W2110891877 @default.
• W4313331521 cites W2112787776 @default.
• W4313331521 cites W2113420540 @default.
• W4313331521 cites W2117770689 @default.
• W4313331521 cites W2117998345 @default.
• W4313331521 cites W2142203996 @default.
• W4313331521 cites W215195587 @default.
• W4313331521 cites W2159220993 @default.
• W4313331521 cites W2159972238 @default.
• W4313331521 cites W2314654345 @default.
• W4313331521 cites W4229706053 @default.
• W4313331521 cites W4247186239 @default.
• W4313331521 cites W58557928 @default.
• W4313331521 cites W74254474 @default.
• W4313331521 doi "https://doi.org/10.4049/jimmunol.161.10.5555" @default.
• W4313331521 hasPublicationYear "1998" @default.
• W4313331521 type Work @default.
• W4313331521 citedByCount "14" @default.
• W4313331521 countsByYear W43133315212014 @default.
• W4313331521 countsByYear W43133315212016 @default.
• W4313331521 countsByYear W43133315212023 @default.
• W4313331521 crossrefType "journal-article" @default.
• W4313331521 hasAuthorship W4313331521A5015560149 @default.
• W4313331521 hasAuthorship W4313331521A5025976004 @default.
• W4313331521 hasAuthorship W4313331521A5027241068 @default.
• W4313331521 hasAuthorship W4313331521A5037565260 @default.
• W4313331521 hasAuthorship W4313331521A5060051979 @default.
• W4313331521 hasAuthorship W4313331521A5077589394 @default.
• W4313331521 hasAuthorship W4313331521A5091287803 @default.
• W4313331521 hasBestOaLocation W43133315211 @default.
• W4313331521 hasConcept C104292427 @default.
• W4313331521 hasConcept C104317684 @default.
• W4313331521 hasConcept C126619667 @default.
• W4313331521 hasConcept C175818844 @default.
• W4313331521 hasConcept C183786373 @default.
• W4313331521 hasConcept C185592680 @default.
• W4313331521 hasConcept C2776165026 @default.
• W4313331521 hasConcept C2776179587 @default.
• W4313331521 hasConcept C42362537 @default.
• W4313331521 hasConcept C502942594 @default.
• W4313331521 hasConcept C55493867 @default.
• W4313331521 hasConcept C62478195 @default.
• W4313331521 hasConcept C86803240 @default.
• W4313331521 hasConcept C95444343 @default.
• W4313331521 hasConceptScore W4313331521C104292427 @default.
• W4313331521 hasConceptScore W4313331521C104317684 @default.
• W4313331521 hasConceptScore W4313331521C126619667 @default.
• W4313331521 hasConceptScore W4313331521C175818844 @default.
• W4313331521 hasConceptScore W4313331521C183786373 @default.
• W4313331521 hasConceptScore W4313331521C185592680 @default.

• next