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- W4313331639 abstract "Lipid metabolism and endoplasmic reticulum (ER) stress play an important role in the progression and metastasis of hepatocellular carcinoma (HCC). We aimed to establish lipid droplet (LD)-associated and ER stress-related gene risk signature as prognostic indicators.Literature searches for LD-associated proteins was screened and validated in The Cancer Genome Atlas (TCGA) and International Cancer Genome Collaboratory (ICGC) databases. A total of 371 samples were enrolled from the TCGA RNA-seq dataset (training cohort) and 240 samples from IGGC RNA-seq dataset (validation cohort). A 10-gene risk signature was established by the last absolute shrinkage and selection operator (LASSO) regression analysis. The prognostic value of the risk signature was evaluated by Cox regression, Kaplan-Meier and ROC Curve analyses. Biological features associated with LD and ER stress-related factors were explored by functional analysis and in vitro experiment.Based on the medical literatures, 124 lipid droplet-associated proteins were retrieved, and three genes failed to establish a valid prognostic model. ER stress was considered as an important component by functional analysis. A 10-gene risk signature compared the clinicopathology characteristics, immunosuppressive events and a nomogram in HCC patients.LD-associated and ER stress-related gene risk signatures highlighted poor prognosis for clinicopathological features, positively correlate with macrophages and T cell immunoglobulin and mucin-3 (TIM-3) expression in the tumor microenvironment, and might act as independent prognostic factors." @default.
- W4313331639 created "2023-01-06" @default.
- W4313331639 creator A5041093397 @default.
- W4313331639 creator A5081853954 @default.
- W4313331639 date "2022-12-29" @default.
- W4313331639 modified "2023-10-13" @default.
- W4313331639 title "Characterization of a lipid droplet and endoplasmic reticulum stress related gene risk signature to evaluate the clinical and biological value in hepatocellular carcinoma" @default.
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- W4313331639 doi "https://doi.org/10.1186/s12944-022-01759-y" @default.
- W4313331639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581927" @default.
- W4313331639 hasPublicationYear "2022" @default.
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- W4313331639 hasAuthorship W4313331639A5041093397 @default.
- W4313331639 hasAuthorship W4313331639A5081853954 @default.