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- W4313331746 startingPage "4472" @default.
- W4313331746 abstract "Abstract Although senescent BALB/c mice (∼2 years old) have reduced numbers of small pre-B cells, early pre-B cells (CD43+CD25+B220+) are present in comparable numbers within the bone marrow of both young (3–6-month-old) and senescent BALB/c mice. The transition of CD43+ pre-B cells to the CD43− pre-B cell compartments is dependent on proliferation and clonal maturation dictated by the pre-B cell receptor (μ/λ5/VpreB). In vivo, senescent CD43+B220+ pro-B/early pre-B cells demonstrated reduction of λ5 mRNA, by RT-PCR analysis, and of both surface and cytoplasmic λ5 protein. Decreased λ5 protein expression was also seen among pro-B/pre-B cells derived from senescent bone marrow after stimulation in vitro with IL-7. We propose that diminished expression of the λ5 surrogate light chain results in decreased pre-B cell receptor formation and contributes to reduced recruitment of nascent CD43+ pre-B cells into the CD43− large and small pre-B cell compartments." @default.
- W4313331746 created "2023-01-06" @default.
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- W4313331746 date "1998-11-01" @default.
- W4313331746 modified "2023-10-06" @default.
- W4313331746 title "Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment" @default.
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- W4313331746 doi "https://doi.org/10.4049/jimmunol.161.9.4472" @default.
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