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- W4313331836 abstract "Abstract Tissue mast cell development requires stem cell factor (SCF), whereas helminth-induced intestinal mucosal mast cell hyperplasia also requires T cell-derived factors such as IL-3. We generated progenitor mast cells (PrMC) from mouse bone marrow cells (BMC) in vitro with a triad of SCF, IL-6, and IL-10 that exhibit IL-3-mediated mitogenic and maturation responses. SCF/IL-6/IL-10 transiently elicited a cell subpopulation with the phenotype (c-kithighThy-1low) of fetal blood promastocytes at 3 wk of culture that progressed within 1 wk to FcεRI-bearing PrMC, designated PrMCTriad. PrMCTriad lacked mouse mast cell carboxypeptidase A (mMC-CPA) protein, required SCF for IL-3-driven thymidine incorporation, and responded to SCF plus IL-3 with strong mMc-CPA immunoreactivity, clarifying distinct sequential roles for SCF and IL-3 in mast cell development. PrMCTriad, arising from BMC through promastocytes, are metamastocytes that acquire microenvironmentally determined phenotypic features." @default.
- W4313331836 created "2023-01-06" @default.
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- W4313331836 date "1998-11-15" @default.
- W4313331836 modified "2023-10-18" @default.
- W4313331836 title "Cutting Edge: Generation of a Novel Stem Cell Factor-Dependent Mast Cell Progenitor" @default.
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- W4313331836 doi "https://doi.org/10.4049/jimmunol.161.10.5143" @default.
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