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• W4313331888 endingPage "4403" @default.
• W4313331888 startingPage "4396" @default.
• W4313331888 abstract "Abstract The cell adhesion molecules (CAMs) required for T lymphocyte recruitment during pulmonary immune responses have not been defined. Our laboratories recently reported that intratracheal (IT) challenge of sensitized mice with SRBC induced prolonged expression of vascular P-selectin, E-selectin, and VCAM-1, particularly in areas of mononuclear leukocyte infiltration. A surge in the number of circulating T lymphocytes expressing selectin ligands preceded the peak accumulation of T cells in the lung. In addition, a significant percentage of the T cells recovered from the lung expressed selectin ligands as well. The current study demonstrates that cultured T lymphoblasts use both selectin ligands and α4 integrins to enter the airspace and interstitium during the response to SRBC. Fluorescently labeled T lymphoblasts, derived via activation on CD3 and growth in low dose IL-2, showed inflammation-specific recruitment into lungs harvested 24 h after cell infusion. Their flux paralleled the accumulation of host lymphocytes in the lung, with both peaking 2 to 4 days after SRBC challenge. Trafficking studies conducted over a 24-h period during peak lymphocyte accumulation in the lungs revealed preferential recruitment of labeled T lymphoblasts expressing P- and E-selectin ligands. In addition, mAb blockade of the α4 integrins and targeted deletion of an α(1,3)fucosyltransferase essential for selectin ligand synthesis each reduced labeled T lymphoblast trafficking to a significant degree. Furthermore, α4 integrin blockade reduced the trafficking of the selectin ligand-deficient cells into the airspace, confirming that its contribution is in part independent from the vascular selectins. These findings imply that both selectin ligands and α4 integrins participate in T lymphoblast recruitment during the pulmonary immune response to IT SRBC." @default.
• W4313331888 created "2023-01-06" @default.
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• W4313331888 date "1998-10-15" @default.
• W4313331888 modified "2023-10-17" @default.
• W4313331888 title "Endothelial Selectins and α4 Integrins Regulate Independent Pathways of T Lymphocyte Recruitment in the Pulmonary Immune Response" @default.
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• W4313331888 doi "https://doi.org/10.4049/jimmunol.161.8.4396" @default.
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