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- W4313331931 endingPage "877" @default.
- W4313331931 startingPage "871" @default.
- W4313331931 abstract "Abstract Like Ig genes, TCR genes are formed by somatic rearrangements of noncontiguous genomic V, J, and C regions. Unlike Ig genes, somatic hypermutation of TCR V regions is an infrequent event. We describe the occurrence of spontaneous hypermutation in a nonproductively rearranged TCR α-chain gene in a clonal T cell hybridoma that had lost its productively rearranged α-chain. The mutating hybridoma was eventually supplanted in culture by a nonmutating variant that had restored an open reading frame in the nonproductively rearranged TCR α-chain through the use of cryptic splice sites in the Vα region. Evidence is presented for the presence of cDNA reverse transcripts of the TCR α-chain within the hybridoma, suggesting a role for reverse transcriptase in the generation of mutations." @default.
- W4313331931 created "2023-01-06" @default.
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- W4313331931 date "1999-01-15" @default.
- W4313331931 modified "2023-10-03" @default.
- W4313331931 title "Alternative Splicing and Hypermutation of a Nonproductively Rearranged TCR α-Chain in a T Cell Hybridoma" @default.
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- W4313331931 doi "https://doi.org/10.4049/jimmunol.162.2.871" @default.
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