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- W4313331964 abstract "Abstract We examined whether γδ T and αβ T cells accumulating in early B16 melanoma lesions regulate NK and NK T cells that attack tumor cells. Freshly isolated and cultured tumor-infiltrating lymphocyte (TIL) populations of NK and NK T cells lysed B16 and produced IFN-γ, whereas γδ T and a large part of αβ T cell populations had no substantial cytotoxicity against B16 and secreted Th2 cytokines. Furthermore, the freshly isolated NK1.1+ TIL population exhibited a higher anti-B16 effect than did splenocytes. γδ T and αβ T cell populations dramatically inhibited the cytotoxicity of NK and NK T cells in an MHC Kb-dependent manner. Culture supernatant from γδ T and αβ T cell populations inhibited the proliferation of NK and NK T cell populations but did not affect their cytotoxicity, suggesting that the released Th2 cytokines are merely partly involved in the down-modulation of NK-lineage cells. NK1.1+ cells obtained from TIL of γδ T cell-depleted mice significantly lysed B16 cells compared with those from control mice. Finally, anti-Kb Fab mAb injected intralesionally at an early, but not at a late, stage of development of B16 melanoma inhibited tumor growth. These findings suggest that Th2-type γδ T and αβ T cells infiltrating in early B16 development inhibit the tumoricidal activity of NK-lineage cells using their class I molecules and partly their suppressive cytokines." @default.
- W4313331964 created "2023-01-06" @default.
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- W4313331964 date "1998-10-15" @default.
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- W4313331964 title "Down-Regulation of Tumoricidal NK and NK T Cell Activities by MHC Kb Molecules Expressed on Th2-Type γδ T and αβ T Cells Coinfiltrating in Early B16 Melanoma Lesions" @default.
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- W4313331964 doi "https://doi.org/10.4049/jimmunol.161.8.4138" @default.
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