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• W4313332019 endingPage "979" @default.
• W4313332019 startingPage "974" @default.
• W4313332019 abstract "Abstract CB6F1 mice display intermediate susceptibility to Leishmania major infection compared with the highly susceptible BALB/c and resistant C57BL/6 parental strains. During early weeks of infection, these mice develop dominant Th2 type responses to L. major, although they eventually exhibit a Th2 to Th1 switch and spontaneously resolve their infections. In this study, we have examined the effects of either IL-12 or anti-TGF-β therapy on the immune response and course of disease in chronically infected CB6F1 mice. Local treatment with IL-12 inoculated into the parasitized lesion at 4 wk of infection induced a marked increase in IFN-γ production but did not result in a significant reduction in numbers of parasite or promote more rapid healing. However, local treatment with an Ab to TGF-β led to both a decrease in parasite numbers and more rapid healing, despite the fact that such treatment did not significantly alter the pattern of IL-4 and IFN-γ production. Immunohistochemical studies showed that anti-TGF-β treatment resulted in increased nitric oxide production within parasitized lesions. Our results suggest that TGF-β may play an important regulatory role during chronic stages of a L. major infection by suppressing macrophage production of nitric oxide and that, in the absence of TGF-β, even the relatively low levels of IFN-γ observed in mice with dominant Th2-type responses are sufficient to activate macrophages to destroy amastigotes within parasitized lesions." @default.
• W4313332019 created "2023-01-06" @default.
• W4313332019 creator A5003951398 @default.
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• W4313332019 date "1999-01-15" @default.
• W4313332019 modified "2023-10-14" @default.
• W4313332019 title "Anti-TGF-β Treatment Promotes Rapid Healing of<i>Leishmania major</i>Infection in Mice by Enhancing In Vivo Nitric Oxide Production" @default.
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• W4313332019 doi "https://doi.org/10.4049/jimmunol.162.2.974" @default.
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