Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313332515> ?p ?o ?g. }
- W4313332515 abstract "Thyroid hormone excess secondary to global type 3 deiodinase (DIO3) deficiency leads to increased locomotor activity and reduced adiposity, but also to concurrent alterations in parameters of the leptin-melanocortin system that would predict obesity. To distinguish the underlying contributions to the energy balance phenotype of DIO3 deficiency, we generated mice with thyroid hormone excess targeted to pro-opiomelanocortin (POMC)-expressing cells via cell-specific DIO3 inactivation. These mice exhibit a male-specific phenotype of reduced hypothalamic Pomc expression, hyperphagia, and increased activity in brown adipose tissue, with adiposity and serum levels of leptin and thyroid hormones remained normal. These male mice also manifest a marked and widespread hypothalamic reduction in the expression of bone morphogenetic receptor 1a (BMPR1A), which has been shown to cause similar phenotypes when inactivated in POMC-expressing cells. Our results indicate that developmental overexposure to thyroid hormone in POMC-expressing cells programs energy balance mechanisms in a sexually dimorphic manner by suppressing adult hypothalamic BMPR1A expression." @default.
- W4313332515 created "2023-01-06" @default.
- W4313332515 creator A5004332317 @default.
- W4313332515 creator A5030192169 @default.
- W4313332515 creator A5052406385 @default.
- W4313332515 creator A5070424171 @default.
- W4313332515 creator A5071479173 @default.
- W4313332515 date "2022-09-01" @default.
- W4313332515 modified "2023-09-30" @default.
- W4313332515 title "Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation" @default.
- W4313332515 cites W1532178599 @default.
- W4313332515 cites W1546146845 @default.
- W4313332515 cites W1587621508 @default.
- W4313332515 cites W1598714070 @default.
- W4313332515 cites W1606910233 @default.
- W4313332515 cites W1839206181 @default.
- W4313332515 cites W1853192652 @default.
- W4313332515 cites W1965462646 @default.
- W4313332515 cites W1974128885 @default.
- W4313332515 cites W1975219938 @default.
- W4313332515 cites W1975909673 @default.
- W4313332515 cites W1977398830 @default.
- W4313332515 cites W1984548515 @default.
- W4313332515 cites W1991290726 @default.
- W4313332515 cites W1994310297 @default.
- W4313332515 cites W1995618605 @default.
- W4313332515 cites W1997209292 @default.
- W4313332515 cites W2002473707 @default.
- W4313332515 cites W2003795436 @default.
- W4313332515 cites W2006889378 @default.
- W4313332515 cites W2019259772 @default.
- W4313332515 cites W2023126007 @default.
- W4313332515 cites W2027083548 @default.
- W4313332515 cites W2043548753 @default.
- W4313332515 cites W2045703150 @default.
- W4313332515 cites W2047024738 @default.
- W4313332515 cites W2049813666 @default.
- W4313332515 cites W2058526650 @default.
- W4313332515 cites W2063595480 @default.
- W4313332515 cites W2075480833 @default.
- W4313332515 cites W2079359536 @default.
- W4313332515 cites W2082844581 @default.
- W4313332515 cites W2096114331 @default.
- W4313332515 cites W2101123075 @default.
- W4313332515 cites W2110478478 @default.
- W4313332515 cites W2116365106 @default.
- W4313332515 cites W2117349657 @default.
- W4313332515 cites W2118393645 @default.
- W4313332515 cites W2119818391 @default.
- W4313332515 cites W2125228007 @default.
- W4313332515 cites W2134898018 @default.
- W4313332515 cites W2155560632 @default.
- W4313332515 cites W2162716270 @default.
- W4313332515 cites W2164577763 @default.
- W4313332515 cites W2181871939 @default.
- W4313332515 cites W2219905890 @default.
- W4313332515 cites W2220080692 @default.
- W4313332515 cites W2265698540 @default.
- W4313332515 cites W2510265237 @default.
- W4313332515 cites W2516680938 @default.
- W4313332515 cites W2557571313 @default.
- W4313332515 cites W2576537655 @default.
- W4313332515 cites W2588515832 @default.
- W4313332515 cites W2625840978 @default.
- W4313332515 cites W2763230292 @default.
- W4313332515 cites W2974259829 @default.
- W4313332515 cites W2981214749 @default.
- W4313332515 cites W2999734416 @default.
- W4313332515 cites W3084963753 @default.
- W4313332515 cites W3110794262 @default.
- W4313332515 cites W3116768565 @default.
- W4313332515 cites W3133682998 @default.
- W4313332515 cites W3135722816 @default.
- W4313332515 cites W3137585422 @default.
- W4313332515 cites W3145150530 @default.
- W4313332515 cites W3158734823 @default.
- W4313332515 cites W3175943938 @default.
- W4313332515 cites W4205943196 @default.
- W4313332515 doi "https://doi.org/10.1093/jmcb/mjac078" @default.
- W4313332515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581316" @default.
- W4313332515 hasPublicationYear "2022" @default.
- W4313332515 type Work @default.
- W4313332515 citedByCount "1" @default.
- W4313332515 countsByYear W43133325152022 @default.
- W4313332515 crossrefType "journal-article" @default.
- W4313332515 hasAuthorship W4313332515A5004332317 @default.
- W4313332515 hasAuthorship W4313332515A5030192169 @default.
- W4313332515 hasAuthorship W4313332515A5052406385 @default.
- W4313332515 hasAuthorship W4313332515A5070424171 @default.
- W4313332515 hasAuthorship W4313332515A5071479173 @default.
- W4313332515 hasBestOaLocation W43133325151 @default.
- W4313332515 hasConcept C104317684 @default.
- W4313332515 hasConcept C113214860 @default.
- W4313332515 hasConcept C126322002 @default.
- W4313332515 hasConcept C127716648 @default.
- W4313332515 hasConcept C134018914 @default.
- W4313332515 hasConcept C171089720 @default.
- W4313332515 hasConcept C2776515397 @default.
- W4313332515 hasConcept C2777003273 @default.
- W4313332515 hasConcept C2778288131 @default.