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- W4313332550 abstract "Developmental robustness represents the ability of an organism to resist phenotypic variations despite environmental insults and inherent genetic variations. Derailment of developmental robustness leads to phenotypic variations that can get fixed in a population for many generations. Environmental pollution is a significant worldwide problem with detrimental consequences of human development. Understanding the genetic basis for how pollutants affect human development is critical for developing interventional therapies. Here, we report that environmental stress induced by hexavalent chromium, Cr(VI), a potent industrial pollutant, compromises developmental robustness, leading to phenotypic variations in the progeny. These phenotypic variations arise due to epigenetic instability and transposon activation in the somatic tissues of the progeny rather than novel genetic mutations and can be reduced by increasing the dosage of Piwi - a Piwi-interacting RNA-binding protein, in the ovary of the exposed mother. Significantly, the derailment of developmental robustness by Cr(VI) exposure leads to tumors in the progeny, and the predisposition to develop tumors is fixed in the population for at least three generations. Thus, we show for the first time that environmental pollution can derail developmental robustness and predispose the progeny of the exposed population to develop phenotypic variations and tumors." @default.
- W4313332550 created "2023-01-06" @default.
- W4313332550 creator A5027019889 @default.
- W4313332550 creator A5034731952 @default.
- W4313332550 date "2022-12-28" @default.
- W4313332550 modified "2023-10-18" @default.
- W4313332550 title "Hexavalent chromium–induced epigenetic instability and transposon activation lead to phenotypic variations and tumors in <i>Drosophila</i>" @default.
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- W4313332550 doi "https://doi.org/10.1093/eep/dvac030" @default.
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- W4313332550 hasPublicationYear "2022" @default.
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