FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313332555> ?p ?o ?g. }

• W4313332555 abstract "Pneumoconiosis is the most common and serious disease among coal miners. In earlier work on this subject, we documented that coal dust (CD) nanoparticles (CD-NPs) induced pulmonary fibrosis (PF) more profoundly than did CD micron particles (CD-MPs), but the mechanism has not been thoroughly studied. Based on the GEO database, jveen, STRING, and Cytoscape tools were used to screen hub genes regulating PF. Particle size distribution of CD were analyzed with Malvern nanoparticle size potentiometer. Combining 8 computational methods, we found that IGF1, POSTN, MMP7, ASPN, and CXCL14 may act as hub genes regulating PF. Based on the high score of IGF1 and its important regulatory role in various tissue fibrosis, we selected it as the target gene in this study. Activation of the IGF1/IGF1R axis promoted CD-NPs-induced PF, and inhibition of the axis activation had the opposite effect in vitro and in vivo. Furthermore, activation of the IGF1/IGF1R axis induced generation of reactive oxygen species (ROS) to promote epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AECs) to accelerate PF. High-throughput gene sequencing based on lung tissue suggested that cytokine-cytokine receptor interaction and the NF-kB signaling pathway play a key role in PF. Also, ROS induced inflammation and EMT by the activation of the NF-kB/NLRP3 axis to accelerate PF. ROS can induce the activation of AKT/GSK3β signaling, and inhibition of it can inhibit ROS-induced inflammation and EMT by the NF-kB/NLRP3 axis, thereby inhibiting PF. CD-NPs induced PF by promoting inflammation and EMT via the NF-κB/NLRP3 pathway driven by IGF1/ROS-mediated AKT/GSK3β signals. This study provides a valuable experimental basis for the prevention and treatment of coal workers' pneumoconiosis. Illustration of the overall research idea of this study: IGF1 stimulates coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and EMT via the NF-κB/NLRP3 pathway driven by ROS-mediated AKT/GSK3β signals." @default.
• W4313332555 created "2023-01-06" @default.
• W4313332555 creator A5010712135 @default.
• W4313332555 creator A5020397284 @default.
• W4313332555 creator A5038066574 @default.
• W4313332555 creator A5038396680 @default.
• W4313332555 creator A5049502957 @default.
• W4313332555 date "2022-12-29" @default.
• W4313332555 modified "2023-10-12" @default.
• W4313332555 title "Coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and epithelial-mesenchymal transition via the NF-κB/NLRP3 pathway driven by IGF1/ROS-mediated AKT/GSK3β signals" @default.
• W4313332555 cites W1505584712 @default.
• W4313332555 cites W1975048104 @default.
• W4313332555 cites W1978678714 @default.
• W4313332555 cites W1989040608 @default.
• W4313332555 cites W1999148207 @default.
• W4313332555 cites W2011351479 @default.
• W4313332555 cites W2017723770 @default.
• W4313332555 cites W2022862004 @default.
• W4313332555 cites W2032809721 @default.
• W4313332555 cites W2053201056 @default.
• W4313332555 cites W2061478827 @default.
• W4313332555 cites W2075927731 @default.
• W4313332555 cites W2078314973 @default.
• W4313332555 cites W2080818814 @default.
• W4313332555 cites W2091945251 @default.
• W4313332555 cites W2108099642 @default.
• W4313332555 cites W2118173129 @default.
• W4313332555 cites W2119341928 @default.
• W4313332555 cites W2135472946 @default.
• W4313332555 cites W2138129903 @default.
• W4313332555 cites W2155118487 @default.
• W4313332555 cites W2220233016 @default.
• W4313332555 cites W2440150054 @default.
• W4313332555 cites W2623637971 @default.
• W4313332555 cites W2746601664 @default.
• W4313332555 cites W2769477185 @default.
• W4313332555 cites W2771424571 @default.
• W4313332555 cites W2792319306 @default.
• W4313332555 cites W2793179989 @default.
• W4313332555 cites W2887949640 @default.
• W4313332555 cites W2889938393 @default.
• W4313332555 cites W2896928442 @default.
• W4313332555 cites W2899375750 @default.
• W4313332555 cites W2903601250 @default.
• W4313332555 cites W2906693960 @default.
• W4313332555 cites W2909611686 @default.
• W4313332555 cites W2911033210 @default.
• W4313332555 cites W2911397810 @default.
• W4313332555 cites W2913506254 @default.
• W4313332555 cites W2914899181 @default.
• W4313332555 cites W2920441445 @default.
• W4313332555 cites W2921452370 @default.
• W4313332555 cites W2954782052 @default.
• W4313332555 cites W2960015172 @default.
• W4313332555 cites W2970008479 @default.
• W4313332555 cites W2982061867 @default.
• W4313332555 cites W2984337944 @default.
• W4313332555 cites W2989734034 @default.
• W4313332555 cites W3010682239 @default.
• W4313332555 cites W3027744990 @default.
• W4313332555 cites W3031748046 @default.
• W4313332555 cites W3081321465 @default.
• W4313332555 cites W3091947140 @default.
• W4313332555 cites W3094025892 @default.
• W4313332555 cites W3102726452 @default.
• W4313332555 cites W3114925727 @default.
• W4313332555 cites W3131363062 @default.
• W4313332555 cites W3137259412 @default.
• W4313332555 cites W3155293385 @default.
• W4313332555 cites W3159250203 @default.
• W4313332555 cites W3182250220 @default.
• W4313332555 cites W3186501287 @default.
• W4313332555 cites W3196500168 @default.
• W4313332555 cites W3209572902 @default.
• W4313332555 cites W4213028821 @default.
• W4313332555 cites W4213103476 @default.
• W4313332555 cites W4221095248 @default.
• W4313332555 cites W4232522532 @default.
• W4313332555 cites W4288686138 @default.
• W4313332555 cites W4288692008 @default.
• W4313332555 cites W2978867056 @default.
• W4313332555 doi "https://doi.org/10.1038/s41420-022-01291-z" @default.
• W4313332555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581638" @default.
• W4313332555 hasPublicationYear "2022" @default.
• W4313332555 type Work @default.
• W4313332555 citedByCount "3" @default.
• W4313332555 countsByYear W43133325552023 @default.
• W4313332555 crossrefType "journal-article" @default.
• W4313332555 hasAuthorship W4313332555A5010712135 @default.
• W4313332555 hasAuthorship W4313332555A5020397284 @default.
• W4313332555 hasAuthorship W4313332555A5038066574 @default.
• W4313332555 hasAuthorship W4313332555A5038396680 @default.
• W4313332555 hasAuthorship W4313332555A5049502957 @default.
• W4313332555 hasBestOaLocation W43133325551 @default.
• W4313332555 hasConcept C104317684 @default.
• W4313332555 hasConcept C127561419 @default.
• W4313332555 hasConcept C142724271 @default.
• W4313332555 hasConcept C185592680 @default.
• W4313332555 hasConcept C190283241 @default.
• W4313332555 hasConcept C203014093 @default.

• next