FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313332679> ?p ?o ?g. }

• W4313332679 abstract "Abstract We compared endogenous ω-3 PUFA production to supplementation for improving obesity-related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous ω-6 to ω-3 PUFA, and wild-type littermates were fed a high-fat diet and a daily dose of either ω-3 or ω-6 PUFA-rich oil for 12 wk. The endogenous ω-3 PUFA production improved glucose intolerance and insulin resistance but not hepatic steatosis. Conversely, ω-3 PUFA supplementation fully prevented hepatic steatosis but failed to improve insulin resistance. Both models increased hepatic levels of ω-3 PUFA-containing 2-monoacylglycerol and N-acylethanolamine congeners, and reduced levels of ω-6 PUFA-derived endocannabinoids with ω-3 PUFA supplementation being more efficacious. Reduced hepatic lipid accumulation associated with the endocannabinoidome metabolites EPEA and DHEA, which was causally demonstrated by lower lipid accumulation in oleic acid-treated hepatic cells treated with these metabolites. While both models induced a significant fecal enrichment of the beneficial Allobaculum genus, mice supplemented with ω-3 PUFA displayed additional changes in the gut microbiota functions with a significant reduction of fecal levels of the proinflammatory molecules lipopolysaccharide and flagellin. Multiple-factor analysis identify that the metabolic improvements induced by ω-3 PUFAs were accompanied by a reduced production of the proinflammatory cytokine TNFα, and that ω-3 PUFA supplementation had a stronger effect on improving the hepatic fatty acid profile than endogenous ω-3 PUFA. While endogenous ω-3 PUFA production preferably improves glucose tolerance and insulin resistance, ω-3 PUFA intake appears to be required to elicit selective changes in hepatic endocannabinoidome signaling that are essential to alleviate high-fat diet-induced hepatic steatosis." @default.
• W4313332679 created "2023-01-06" @default.
• W4313332679 creator A5000026424 @default.
• W4313332679 creator A5007768979 @default.
• W4313332679 creator A5018718565 @default.
• W4313332679 creator A5020808506 @default.
• W4313332679 creator A5029158702 @default.
• W4313332679 creator A5030599421 @default.
• W4313332679 creator A5036203001 @default.
• W4313332679 creator A5036949458 @default.
• W4313332679 creator A5037814785 @default.
• W4313332679 creator A5043538085 @default.
• W4313332679 creator A5045412833 @default.
• W4313332679 creator A5045420349 @default.
• W4313332679 creator A5053674677 @default.
• W4313332679 creator A5055343931 @default.
• W4313332679 creator A5058227452 @default.
• W4313332679 creator A5063503336 @default.
• W4313332679 creator A5075026770 @default.
• W4313332679 creator A5076876235 @default.
• W4313332679 creator A5079262202 @default.
• W4313332679 creator A5079487846 @default.
• W4313332679 creator A5085020704 @default.
• W4313332679 creator A5087646724 @default.
• W4313332679 date "2022-12-29" @default.
• W4313332679 modified "2023-10-17" @default.
• W4313332679 title "Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders" @default.
• W4313332679 cites W1898209861 @default.
• W4313332679 cites W1966778844 @default.
• W4313332679 cites W1969422680 @default.
• W4313332679 cites W1974660368 @default.
• W4313332679 cites W1981136331 @default.
• W4313332679 cites W1984769120 @default.
• W4313332679 cites W1988925586 @default.
• W4313332679 cites W1998323589 @default.
• W4313332679 cites W2002029801 @default.
• W4313332679 cites W2012715697 @default.
• W4313332679 cites W2021213678 @default.
• W4313332679 cites W2028726702 @default.
• W4313332679 cites W2038831823 @default.
• W4313332679 cites W2044318948 @default.
• W4313332679 cites W2048853985 @default.
• W4313332679 cites W2050024623 @default.
• W4313332679 cites W2052482682 @default.
• W4313332679 cites W2055544117 @default.
• W4313332679 cites W2056658113 @default.
• W4313332679 cites W2059439508 @default.
• W4313332679 cites W2064837899 @default.
• W4313332679 cites W2067141183 @default.
• W4313332679 cites W2069551187 @default.
• W4313332679 cites W2081839805 @default.
• W4313332679 cites W2086865963 @default.
• W4313332679 cites W2089573633 @default.
• W4313332679 cites W2089714176 @default.
• W4313332679 cites W2094230394 @default.
• W4313332679 cites W2095489324 @default.
• W4313332679 cites W2097116634 @default.
• W4313332679 cites W2098208341 @default.
• W4313332679 cites W2099456560 @default.
• W4313332679 cites W2103108588 @default.
• W4313332679 cites W2106348916 @default.
• W4313332679 cites W2111685356 @default.
• W4313332679 cites W2115549894 @default.
• W4313332679 cites W2115860672 @default.
• W4313332679 cites W2123055294 @default.
• W4313332679 cites W2124351063 @default.
• W4313332679 cites W2127010382 @default.
• W4313332679 cites W2133811076 @default.
• W4313332679 cites W2134541386 @default.
• W4313332679 cites W2136879569 @default.
• W4313332679 cites W2151350595 @default.
• W4313332679 cites W2152885278 @default.
• W4313332679 cites W2154664623 @default.
• W4313332679 cites W2168526937 @default.
• W4313332679 cites W2171056359 @default.
• W4313332679 cites W2174180101 @default.
• W4313332679 cites W2206708469 @default.
• W4313332679 cites W2287487780 @default.
• W4313332679 cites W2289293388 @default.
• W4313332679 cites W2313423400 @default.
• W4313332679 cites W2315894353 @default.
• W4313332679 cites W2396003270 @default.
• W4313332679 cites W2415314033 @default.
• W4313332679 cites W2460083407 @default.
• W4313332679 cites W2469023840 @default.
• W4313332679 cites W2529784227 @default.
• W4313332679 cites W2548551915 @default.
• W4313332679 cites W2575198881 @default.
• W4313332679 cites W2606691626 @default.
• W4313332679 cites W2619938137 @default.
• W4313332679 cites W2725005993 @default.
• W4313332679 cites W2756225310 @default.
• W4313332679 cites W2766644732 @default.
• W4313332679 cites W2772974937 @default.
• W4313332679 cites W2796001718 @default.
• W4313332679 cites W2803278092 @default.
• W4313332679 cites W2886437229 @default.
• W4313332679 cites W2914171609 @default.
• W4313332679 cites W2920541859 @default.
• W4313332679 cites W2936783190 @default.

• next