FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313332809> ?p ?o ?g. }

• W4313332809 abstract "Abstract Nivolumab, an immune checkpoint inhibitor is the first-line therapy for platinum-resistant recurrent/metastatic head and neck cancer, and highly effective for some patients. However, no factors have been identified that could predict response or prognosis after nivolumab administration. We retrospectively investigated the association between tumor infiltrating lymphocytes (TILs) of initial pathology and prognosis in patients treated with nivolumab. Twenty-eight patients with human papilloma virus and Epstein–Barr virus unrelated head and neck squamous cell carcinoma were enrolled. CD8 + cells, FoxP3 + cells and FoxP3 − CD4 + cells in the tumoral and peritumoral stromal area and PD-L1 were measured. In result, FoxP3 − CD4 + TIL, FoxP3 + TIL, and CD8 + TIL were not correlated with survival in either intratumoral and stromal area. In univariate analysis, objective response was significant prognostic factor both in progression-free survival and overall survival ( p = 0.01, 0.006, respectively). PD-L1 was also significant prognostic factor both in progression-free survival and overall survival ( p = 0.01, 0.01, respectively). ECOG Performance status was a significant prognostic factor in overall survival ( p = 0.0009). In the combined analysis of stromal CD8 + TIL and PD-L1, PD-L1 positive with high stromal CD8 + TIL subgroups had a better prognosis than PD-L1 negative with low stromal CD8 + TIL subgroups in progression-free survival ( p = 0.006). Although these results require a further investigation, PD-L1 and ECOG Performance status and the combination of stromal CD8 + TIL and PD-L1 positivity have potential as useful prognostic markers in patients of virus unrelated head and neck squamous cell carcinoma treated with nivolumab." @default.
• W4313332809 created "2023-01-06" @default.
• W4313332809 creator A5007350359 @default.
• W4313332809 creator A5016815860 @default.
• W4313332809 creator A5029350033 @default.
• W4313332809 creator A5033780369 @default.
• W4313332809 creator A5052392647 @default.
• W4313332809 creator A5057954384 @default.
• W4313332809 creator A5071824408 @default.
• W4313332809 creator A5074846269 @default.
• W4313332809 creator A5082350005 @default.
• W4313332809 creator A5082782744 @default.
• W4313332809 creator A5089141878 @default.
• W4313332809 creator A5091440848 @default.
• W4313332809 date "2022-12-29" @default.
• W4313332809 modified "2023-10-01" @default.
• W4313332809 title "A retrospective analysis of tumor infiltrating lymphocytes in head and neck squamous cell carcinoma patients treated with nivolumab" @default.
• W4313332809 cites W1889335134 @default.
• W4313332809 cites W1970151745 @default.
• W4313332809 cites W2002726823 @default.
• W4313332809 cites W2120431466 @default.
• W4313332809 cites W2121960517 @default.
• W4313332809 cites W2419439766 @default.
• W4313332809 cites W2529484692 @default.
• W4313332809 cites W2531648809 @default.
• W4313332809 cites W2559382297 @default.
• W4313332809 cites W2591717879 @default.
• W4313332809 cites W2625997216 @default.
• W4313332809 cites W2732036046 @default.
• W4313332809 cites W2737785069 @default.
• W4313332809 cites W2744621424 @default.
• W4313332809 cites W2788797147 @default.
• W4313332809 cites W2797235109 @default.
• W4313332809 cites W2884018817 @default.
• W4313332809 cites W2892292293 @default.
• W4313332809 cites W2912228357 @default.
• W4313332809 cites W2951296513 @default.
• W4313332809 cites W2971761467 @default.
• W4313332809 cites W2982023685 @default.
• W4313332809 cites W2986633517 @default.
• W4313332809 cites W2991483702 @default.
• W4313332809 cites W3000218019 @default.
• W4313332809 cites W3028153189 @default.
• W4313332809 cites W3028510743 @default.
• W4313332809 cites W3098349316 @default.
• W4313332809 cites W3100953153 @default.
• W4313332809 cites W3102118357 @default.
• W4313332809 cites W3130979972 @default.
• W4313332809 cites W3154612073 @default.
• W4313332809 cites W3181752997 @default.
• W4313332809 cites W3196906575 @default.
• W4313332809 cites W3200816639 @default.
• W4313332809 cites W4220905116 @default.
• W4313332809 doi "https://doi.org/10.1038/s41598-022-27237-0" @default.
• W4313332809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36581686" @default.
• W4313332809 hasPublicationYear "2022" @default.
• W4313332809 type Work @default.
• W4313332809 citedByCount "2" @default.
• W4313332809 countsByYear W43133328092023 @default.
• W4313332809 crossrefType "journal-article" @default.
• W4313332809 hasAuthorship W4313332809A5007350359 @default.
• W4313332809 hasAuthorship W4313332809A5016815860 @default.
• W4313332809 hasAuthorship W4313332809A5029350033 @default.
• W4313332809 hasAuthorship W4313332809A5033780369 @default.
• W4313332809 hasAuthorship W4313332809A5052392647 @default.
• W4313332809 hasAuthorship W4313332809A5057954384 @default.
• W4313332809 hasAuthorship W4313332809A5071824408 @default.
• W4313332809 hasAuthorship W4313332809A5074846269 @default.
• W4313332809 hasAuthorship W4313332809A5082350005 @default.
• W4313332809 hasAuthorship W4313332809A5082782744 @default.
• W4313332809 hasAuthorship W4313332809A5089141878 @default.
• W4313332809 hasAuthorship W4313332809A5091440848 @default.
• W4313332809 hasBestOaLocation W43133328091 @default.
• W4313332809 hasConcept C121608353 @default.
• W4313332809 hasConcept C126322002 @default.
• W4313332809 hasConcept C143998085 @default.
• W4313332809 hasConcept C144301174 @default.
• W4313332809 hasConcept C167672396 @default.
• W4313332809 hasConcept C16930146 @default.
• W4313332809 hasConcept C203014093 @default.
• W4313332809 hasConcept C2776530083 @default.
• W4313332809 hasConcept C2776833033 @default.
• W4313332809 hasConcept C2777701055 @default.
• W4313332809 hasConcept C2778326572 @default.
• W4313332809 hasConcept C2779727006 @default.
• W4313332809 hasConcept C2780030458 @default.
• W4313332809 hasConcept C38180746 @default.
• W4313332809 hasConcept C502942594 @default.
• W4313332809 hasConcept C71924100 @default.
• W4313332809 hasConcept C8891405 @default.
• W4313332809 hasConceptScore W4313332809C121608353 @default.
• W4313332809 hasConceptScore W4313332809C126322002 @default.
• W4313332809 hasConceptScore W4313332809C143998085 @default.
• W4313332809 hasConceptScore W4313332809C144301174 @default.
• W4313332809 hasConceptScore W4313332809C167672396 @default.
• W4313332809 hasConceptScore W4313332809C16930146 @default.
• W4313332809 hasConceptScore W4313332809C203014093 @default.
• W4313332809 hasConceptScore W4313332809C2776530083 @default.
• W4313332809 hasConceptScore W4313332809C2776833033 @default.
• W4313332809 hasConceptScore W4313332809C2777701055 @default.

• next