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- W4313332959 abstract "Abstract The bacterial peptidoglycan (PGN) constituent muramyl dipeptide (MDP) and its congeners possess immuno-adjuvant activity, and find applications in vaccines to potentiate the immune response of antigens. It confers non-specific resistance towards pathogenic infections and defense against tumors. In this work, the parent MDP molecule is re-designed by replacing its carbohydrate moiety with an immunoregulatory xanthine scaffold, while conserving the l-d configuration of the pharmacophore. Alkyl chains are introduced at the C-terminus of d-isoglutamine to help the molecules access cytoplasmic NOD2 receptors and activate the innate immune system. Lipophilic MDP congeners are thus obtained by adopting a direct or indirect convergent synthetic route with overall yields of >50%. We found that an indirect approach can reliably be implemented on gram scale, thereby unlocking access to substantial amounts of pathogen-associated molecular patterns for in vivo studies, which will accelerate the development of NOD2 immuno-adjuvants against viral and bacterial infections." @default.
- W4313332959 created "2023-01-06" @default.
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- W4313332959 date "2022-12-29" @default.
- W4313332959 modified "2023-10-17" @default.
- W4313332959 title "A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation" @default.
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- W4313332959 doi "https://doi.org/10.1055/a-2004-5883" @default.
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