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• W4313333079 abstract "Phosphates and polyphosphates play ubiquitous roles in biology as integral structural components of cell membranes and bone, or as vehicles of energy storage via adenosine triphosphate and phosphocreatine. The solution phase space of phosphate species appears more complex than previously known. We present nuclear magnetic resonance (NMR) and cryogenic transmission electron microscopy (cryo-TEM) experiments that suggest phosphate species including orthophosphates, pyrophosphates, and adenosine phosphates associate into dynamic assemblies in dilute solutions that are spectroscopically dark. Cryo-TEM provides visual evidence of the formation of spherical assemblies tens of nanometers in size, while NMR indicates that a majority population of phosphates remain as unassociated ions in exchange with spectroscopically invisible assemblies. The formation of these assemblies is reversibly and entropically driven by the partial dehydration of phosphate groups, as verified by diffusion-ordered spectroscopy (DOSY), indicating a thermodynamic state of assembly held together by multivalent interactions between the phosphates. Molecular dynamics simulations further corroborate that orthophosphates readily cluster in aqueous solutions. This study presents the surprising discovery that phosphate-containing molecules, ubiquitously present in the biological milieu, can readily form dynamic assemblies under a wide range of commonly used solution conditions, highlighting a hitherto unreported property of phosphate's native state in biological solutions." @default.
• W4313333079 created "2023-01-06" @default.
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• W4313333079 date "2022-12-29" @default.
• W4313333079 modified "2023-10-03" @default.
• W4313333079 title "Phosphates form spectroscopically dark state assemblies in common aqueous solutions" @default.
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• W4313333079 doi "https://doi.org/10.1073/pnas.2206765120" @default.
• W4313333079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36580589" @default.
• W4313333079 hasPublicationYear "2022" @default.
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