Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333671> ?p ?o ?g. }
- W4313333671 endingPage "1471" @default.
- W4313333671 startingPage "1466" @default.
- W4313333671 abstract "Abstract Intra-articular injection of streptococcal cell wall Ag followed by i.v. challenge (“reactivation”) results in a destructive lymphocyte-dependent monoarticular arthritis. To further define the role of immune mechanisms in the model, Abs to Th1 and Th2-related cytokines were evaluated. Treatment of rats with antibodies to IL-4 reduced swelling, while treatment with anti-IL-10 or anti-IFN-γ either had no effect or slightly enhanced the inflammatory response. These results suggest that Th-2 immune mechanisms may be, at least in part, operative in the model. To more precisely define the role of IL-4, the effects of anti-IL-4 on monocyte chemoattractant protein-1 (MCP-1) expression were evaluated. Initial studies demonstrated that mRNA (as determined by in situ hybridization) and protein (as determined by immunofluorescence) for MCP-1 were detectable in inflamed synovial tissue in a time-dependent manner. Anti-IL-4 treatment significantly reduced the expression of mRNA for MCP-1 24 and 72 h after reactivation. In addition, anti-MCP-1 inhibited swelling and reduced influx of 111In-labeled T cells. These data suggest that the reactivation model of streptococcal cell wall Ag-induced arthritis is Th-2 dependent, and that an inter-relationship exists between IL-4 and the expression of MCP-1." @default.
- W4313333671 created "2023-01-06" @default.
- W4313333671 creator A5013511009 @default.
- W4313333671 creator A5030346835 @default.
- W4313333671 creator A5035325770 @default.
- W4313333671 creator A5042966626 @default.
- W4313333671 creator A5043957602 @default.
- W4313333671 creator A5058983458 @default.
- W4313333671 creator A5066984201 @default.
- W4313333671 creator A5073269628 @default.
- W4313333671 creator A5079037869 @default.
- W4313333671 creator A5079367473 @default.
- W4313333671 creator A5079874524 @default.
- W4313333671 date "1998-02-01" @default.
- W4313333671 modified "2023-10-14" @default.
- W4313333671 title "Streptococcal Cell Wall-Induced Arthritis: Requirements for IL-4, IL-10, IFN-γ, and Monocyte Chemoattractant Protein-1" @default.
- W4313333671 cites W1481636931 @default.
- W4313333671 cites W1502030559 @default.
- W4313333671 cites W1502579471 @default.
- W4313333671 cites W1522901397 @default.
- W4313333671 cites W1530149822 @default.
- W4313333671 cites W1545898053 @default.
- W4313333671 cites W1547011386 @default.
- W4313333671 cites W1553420527 @default.
- W4313333671 cites W1595245989 @default.
- W4313333671 cites W1606902694 @default.
- W4313333671 cites W1677381867 @default.
- W4313333671 cites W1853022482 @default.
- W4313333671 cites W1937054431 @default.
- W4313333671 cites W1964756939 @default.
- W4313333671 cites W1965194071 @default.
- W4313333671 cites W1983541797 @default.
- W4313333671 cites W1984299344 @default.
- W4313333671 cites W1991164200 @default.
- W4313333671 cites W2008354469 @default.
- W4313333671 cites W2008377446 @default.
- W4313333671 cites W2008883362 @default.
- W4313333671 cites W2009260285 @default.
- W4313333671 cites W2009806516 @default.
- W4313333671 cites W2011038290 @default.
- W4313333671 cites W2018668472 @default.
- W4313333671 cites W2025638679 @default.
- W4313333671 cites W2032169254 @default.
- W4313333671 cites W2035015850 @default.
- W4313333671 cites W2042329182 @default.
- W4313333671 cites W2061044306 @default.
- W4313333671 cites W2061631826 @default.
- W4313333671 cites W2067350883 @default.
- W4313333671 cites W2068844561 @default.
- W4313333671 cites W2082417827 @default.
- W4313333671 cites W2093446277 @default.
- W4313333671 cites W2099826413 @default.
- W4313333671 cites W2101677486 @default.
- W4313333671 cites W2103210336 @default.
- W4313333671 cites W2110600643 @default.
- W4313333671 cites W2130822808 @default.
- W4313333671 cites W2143951873 @default.
- W4313333671 cites W2165599181 @default.
- W4313333671 cites W2167487061 @default.
- W4313333671 cites W6095822 @default.
- W4313333671 doi "https://doi.org/10.4049/jimmunol.160.3.1466" @default.
- W4313333671 hasPublicationYear "1998" @default.
- W4313333671 type Work @default.
- W4313333671 citedByCount "15" @default.
- W4313333671 countsByYear W43133336712012 @default.
- W4313333671 countsByYear W43133336712014 @default.
- W4313333671 countsByYear W43133336712015 @default.
- W4313333671 countsByYear W43133336712018 @default.
- W4313333671 countsByYear W43133336712022 @default.
- W4313333671 crossrefType "journal-article" @default.
- W4313333671 hasAuthorship W4313333671A5013511009 @default.
- W4313333671 hasAuthorship W4313333671A5030346835 @default.
- W4313333671 hasAuthorship W4313333671A5035325770 @default.
- W4313333671 hasAuthorship W4313333671A5042966626 @default.
- W4313333671 hasAuthorship W4313333671A5043957602 @default.
- W4313333671 hasAuthorship W4313333671A5058983458 @default.
- W4313333671 hasAuthorship W4313333671A5066984201 @default.
- W4313333671 hasAuthorship W4313333671A5073269628 @default.
- W4313333671 hasAuthorship W4313333671A5079037869 @default.
- W4313333671 hasAuthorship W4313333671A5079367473 @default.
- W4313333671 hasAuthorship W4313333671A5079874524 @default.
- W4313333671 hasBestOaLocation W43133336711 @default.
- W4313333671 hasConcept C104317684 @default.
- W4313333671 hasConcept C105580179 @default.
- W4313333671 hasConcept C126322002 @default.
- W4313333671 hasConcept C1491633281 @default.
- W4313333671 hasConcept C153911025 @default.
- W4313333671 hasConcept C159654299 @default.
- W4313333671 hasConcept C170493617 @default.
- W4313333671 hasConcept C185592680 @default.
- W4313333671 hasConcept C203014093 @default.
- W4313333671 hasConcept C2777077863 @default.
- W4313333671 hasConcept C2778236600 @default.
- W4313333671 hasConcept C2781184567 @default.
- W4313333671 hasConcept C54166955 @default.
- W4313333671 hasConcept C55493867 @default.
- W4313333671 hasConcept C71924100 @default.
- W4313333671 hasConcept C81439078 @default.