FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333682> ?p ?o ?g. }

• W4313333682 endingPage "59" @default.
• W4313333682 startingPage "51" @default.
• W4313333682 abstract "Abstract In this study, we demonstrate that human NK cells, human NK clones, the human NK cell line (NK3.3), and a population of murine NK cells can produce the type 2 cytokine IL-13 in response to IL-2 or phorbol myristate acetate plus ionomycin. IL-2 rapidly induced new IL-13 mRNA and protein synthesis in the NK3.3 cell line. Six of 12 human NK clones tested produced IL-13 protein in response to IL-2 or phorbol myristate acetate and ionomycin. Intracellular analysis revealed that ∼2% of human peripheral NK cells produced IL-13 protein in response to IL-2. Isolated NK cells from SCID and RAG-2 knockout (−/−) mice that lack T and B cells as well as normal mice also can produce IL-13 mRNA and protein in response to IL-2. We hypothesized that in the absence of IFN-γ, IL-13-producing NK cells may predominate in vivo. Utilizing IFN-γ knockout (−/−) mice as a model system, IL-2-activated liver NK and T cells expressed 10-fold more IL-13 and IL-5 mRNA and protein than normal controls following IL-2 treatment in vitro. These results suggest that in the absence of IFN-γ, an IL-13- and IL-5-producing NK and T cells predominate in vivo. The existence of this cell type has important implications in innate immunity given that the balance between IFN-γ and IL-13/IL-5-producing NK cells may influence the early development of a cell-mediated or humoral immune response." @default.
• W4313333682 created "2023-01-06" @default.
• W4313333682 creator A5017133195 @default.
• W4313333682 creator A5019215357 @default.
• W4313333682 creator A5045491062 @default.
• W4313333682 creator A5061533999 @default.
• W4313333682 creator A5090914300 @default.
• W4313333682 date "1999-01-01" @default.
• W4313333682 modified "2023-10-17" @default.
• W4313333682 title "IL-13 Production by NK Cells: IL-13-Producing NK and T Cells Are Present In Vivo in the Absence of IFN-γ" @default.
• W4313333682 cites W1479920302 @default.
• W4313333682 cites W1480050981 @default.
• W4313333682 cites W1480871964 @default.
• W4313333682 cites W1504887220 @default.
• W4313333682 cites W1533201237 @default.
• W4313333682 cites W1538777783 @default.
• W4313333682 cites W1546278502 @default.
• W4313333682 cites W1571673987 @default.
• W4313333682 cites W1634119082 @default.
• W4313333682 cites W1635800316 @default.
• W4313333682 cites W1645991544 @default.
• W4313333682 cites W1879871130 @default.
• W4313333682 cites W1919714885 @default.
• W4313333682 cites W1942668068 @default.
• W4313333682 cites W1969912242 @default.
• W4313333682 cites W1970354376 @default.
• W4313333682 cites W1976366517 @default.
• W4313333682 cites W1988563171 @default.
• W4313333682 cites W2001146686 @default.
• W4313333682 cites W2006073656 @default.
• W4313333682 cites W2036274324 @default.
• W4313333682 cites W2038136978 @default.
• W4313333682 cites W2049719443 @default.
• W4313333682 cites W2058860008 @default.
• W4313333682 cites W2062811432 @default.
• W4313333682 cites W2069375902 @default.
• W4313333682 cites W2084072841 @default.
• W4313333682 cites W2084990572 @default.
• W4313333682 cites W2088406835 @default.
• W4313333682 cites W2089262366 @default.
• W4313333682 cites W2092314351 @default.
• W4313333682 cites W2095351296 @default.
• W4313333682 cites W2100366362 @default.
• W4313333682 cites W2108473659 @default.
• W4313333682 cites W2109335002 @default.
• W4313333682 cites W2126464081 @default.
• W4313333682 cites W2128205016 @default.
• W4313333682 cites W2138384967 @default.
• W4313333682 cites W2147720337 @default.
• W4313333682 cites W2153639301 @default.
• W4313333682 cites W2166567151 @default.
• W4313333682 cites W2168728815 @default.
• W4313333682 cites W2171831396 @default.
• W4313333682 cites W2171991650 @default.
• W4313333682 cites W4235204700 @default.
• W4313333682 doi "https://doi.org/10.4049/jimmunol.162.1.51" @default.
• W4313333682 hasPublicationYear "1999" @default.
• W4313333682 type Work @default.
• W4313333682 citedByCount "91" @default.
• W4313333682 countsByYear W43133336822012 @default.
• W4313333682 countsByYear W43133336822013 @default.
• W4313333682 countsByYear W43133336822014 @default.
• W4313333682 countsByYear W43133336822015 @default.
• W4313333682 countsByYear W43133336822016 @default.
• W4313333682 countsByYear W43133336822017 @default.
• W4313333682 countsByYear W43133336822018 @default.
• W4313333682 countsByYear W43133336822019 @default.
• W4313333682 countsByYear W43133336822022 @default.
• W4313333682 countsByYear W43133336822023 @default.
• W4313333682 crossrefType "journal-article" @default.
• W4313333682 hasAuthorship W4313333682A5017133195 @default.
• W4313333682 hasAuthorship W4313333682A5019215357 @default.
• W4313333682 hasAuthorship W4313333682A5045491062 @default.
• W4313333682 hasAuthorship W4313333682A5061533999 @default.
• W4313333682 hasAuthorship W4313333682A5090914300 @default.
• W4313333682 hasBestOaLocation W43133336821 @default.
• W4313333682 hasConcept C129374314 @default.
• W4313333682 hasConcept C136449434 @default.
• W4313333682 hasConcept C149532602 @default.
• W4313333682 hasConcept C153911025 @default.
• W4313333682 hasConcept C154317977 @default.
• W4313333682 hasConcept C183315844 @default.
• W4313333682 hasConcept C202751555 @default.
• W4313333682 hasConcept C203014093 @default.
• W4313333682 hasConcept C2776090121 @default.
• W4313333682 hasConcept C2776989580 @default.
• W4313333682 hasConcept C2778690821 @default.
• W4313333682 hasConcept C28651165 @default.
• W4313333682 hasConcept C55493867 @default.
• W4313333682 hasConcept C79879829 @default.
• W4313333682 hasConcept C86803240 @default.
• W4313333682 hasConcept C8891405 @default.
• W4313333682 hasConcept C95444343 @default.
• W4313333682 hasConceptScore W4313333682C129374314 @default.
• W4313333682 hasConceptScore W4313333682C136449434 @default.
• W4313333682 hasConceptScore W4313333682C149532602 @default.
• W4313333682 hasConceptScore W4313333682C153911025 @default.
• W4313333682 hasConceptScore W4313333682C154317977 @default.

• next