FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333687> ?p ?o ?g. }

• W4313333687 endingPage "2083" @default.
• W4313333687 startingPage "2079" @default.
• W4313333687 abstract "Abstract Fcγ receptors (FcγRII) on B lymphocytes negatively regulate B cell receptor (BCR)-dependent activation upon cross-linking of the two receptors. The mechanism reflects the ability of the FcγRII cytoplasmic tail to recruit specific phosphatases that inactivate elements of the BCR-signaling cascade. We now show that cross-linking also blocks the processing and presentation of BCR-bound Ag. This occurs because the FcγRII isoform typically expressed by B cells (FcγRII-B1) is incompetent for endocytosis. When cross-linked, FcγRII-B1 acts as a dominant negative inhibitor of BCR endocytosis. In contrast, cross-linking of endocytosis-competent FcγRII isoforms did not inhibit endocytosis or processing of BCR-bound Ag. Thus, FcγRII-B1 acts not only to prevent B cell activation under conditions of Ab excess, but also to prevent clonotypic T cell activation by inhibiting the ability of B cells to generate specific MHC class II-bound TCR ligands." @default.
• W4313333687 created "2023-01-06" @default.
• W4313333687 creator A5042210670 @default.
• W4313333687 creator A5085574965 @default.
• W4313333687 creator A5086674978 @default.
• W4313333687 date "1998-09-01" @default.
• W4313333687 modified "2023-10-11" @default.
• W4313333687 title "Cutting Edge: FcγRII-B1 Regulates the Presentation of B Cell Receptor-Bound Antigens" @default.
• W4313333687 cites W1487855049 @default.
• W4313333687 cites W1493447815 @default.
• W4313333687 cites W1513412079 @default.
• W4313333687 cites W1578284751 @default.
• W4313333687 cites W1595980446 @default.
• W4313333687 cites W1675574531 @default.
• W4313333687 cites W1978947335 @default.
• W4313333687 cites W1983940041 @default.
• W4313333687 cites W1984838238 @default.
• W4313333687 cites W1993948601 @default.
• W4313333687 cites W2000061036 @default.
• W4313333687 cites W2004756723 @default.
• W4313333687 cites W2018826402 @default.
• W4313333687 cites W2025862464 @default.
• W4313333687 cites W2031407459 @default.
• W4313333687 cites W2037244730 @default.
• W4313333687 cites W2053142169 @default.
• W4313333687 cites W2055978688 @default.
• W4313333687 cites W2069545269 @default.
• W4313333687 cites W2083673122 @default.
• W4313333687 cites W2084039682 @default.
• W4313333687 cites W2086227162 @default.
• W4313333687 cites W2101073455 @default.
• W4313333687 cites W2101959682 @default.
• W4313333687 cites W2116072610 @default.
• W4313333687 cites W2119204846 @default.
• W4313333687 cites W2130708019 @default.
• W4313333687 cites W213218024 @default.
• W4313333687 cites W2147434547 @default.
• W4313333687 cites W2172099254 @default.
• W4313333687 cites W4250688128 @default.
• W4313333687 doi "https://doi.org/10.4049/jimmunol.161.5.2079" @default.
• W4313333687 hasPublicationYear "1998" @default.
• W4313333687 type Work @default.
• W4313333687 citedByCount "36" @default.
• W4313333687 countsByYear W43133336872012 @default.
• W4313333687 countsByYear W43133336872015 @default.
• W4313333687 crossrefType "journal-article" @default.
• W4313333687 hasAuthorship W4313333687A5042210670 @default.
• W4313333687 hasAuthorship W4313333687A5085574965 @default.
• W4313333687 hasAuthorship W4313333687A5086674978 @default.
• W4313333687 hasBestOaLocation W43133336871 @default.
• W4313333687 hasConcept C108249834 @default.
• W4313333687 hasConcept C117943116 @default.
• W4313333687 hasConcept C147483822 @default.
• W4313333687 hasConcept C153911025 @default.
• W4313333687 hasConcept C157695867 @default.
• W4313333687 hasConcept C159654299 @default.
• W4313333687 hasConcept C170493617 @default.
• W4313333687 hasConcept C170627219 @default.
• W4313333687 hasConcept C185592680 @default.
• W4313333687 hasConcept C19317047 @default.
• W4313333687 hasConcept C203014093 @default.
• W4313333687 hasConcept C207936829 @default.
• W4313333687 hasConcept C2776090121 @default.
• W4313333687 hasConcept C2778453870 @default.
• W4313333687 hasConcept C2779931124 @default.
• W4313333687 hasConcept C28005876 @default.
• W4313333687 hasConcept C43907098 @default.
• W4313333687 hasConcept C55493867 @default.
• W4313333687 hasConcept C86803240 @default.
• W4313333687 hasConcept C8891405 @default.
• W4313333687 hasConcept C95444343 @default.
• W4313333687 hasConceptScore W4313333687C108249834 @default.
• W4313333687 hasConceptScore W4313333687C117943116 @default.
• W4313333687 hasConceptScore W4313333687C147483822 @default.
• W4313333687 hasConceptScore W4313333687C153911025 @default.
• W4313333687 hasConceptScore W4313333687C157695867 @default.
• W4313333687 hasConceptScore W4313333687C159654299 @default.
• W4313333687 hasConceptScore W4313333687C170493617 @default.
• W4313333687 hasConceptScore W4313333687C170627219 @default.
• W4313333687 hasConceptScore W4313333687C185592680 @default.
• W4313333687 hasConceptScore W4313333687C19317047 @default.
• W4313333687 hasConceptScore W4313333687C203014093 @default.
• W4313333687 hasConceptScore W4313333687C207936829 @default.
• W4313333687 hasConceptScore W4313333687C2776090121 @default.
• W4313333687 hasConceptScore W4313333687C2778453870 @default.
• W4313333687 hasConceptScore W4313333687C2779931124 @default.
• W4313333687 hasConceptScore W4313333687C28005876 @default.
• W4313333687 hasConceptScore W4313333687C43907098 @default.
• W4313333687 hasConceptScore W4313333687C55493867 @default.
• W4313333687 hasConceptScore W4313333687C86803240 @default.
• W4313333687 hasConceptScore W4313333687C8891405 @default.
• W4313333687 hasConceptScore W4313333687C95444343 @default.
• W4313333687 hasIssue "5" @default.
• W4313333687 hasLocation W43133336871 @default.
• W4313333687 hasOpenAccess W4313333687 @default.
• W4313333687 hasPrimaryLocation W43133336871 @default.
• W4313333687 hasRelatedWork W2049404226 @default.
• W4313333687 hasRelatedWork W2051067776 @default.

• next