FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333699> ?p ?o ?g. }

• W4313333699 endingPage "194" @default.
• W4313333699 startingPage "186" @default.
• W4313333699 abstract "Abstract CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3α, a CC chemokine chemotactic for lymphocytes and dendritic cells. Using anti-serum that we raised against the N-terminal residues of CCR6, we have characterized the surface expression of CCR6 on peripheral blood leukocytes and we have correlated CCR6 expression with responses to MIP-3α. We found that CCR6 was expressed only on memory T cells, including most α4β7 memory cells and cutaneous lymphocyte-associated Ag-expressing cells, and on B cells. Accordingly, chemotaxis of T cells to MIP-3α was limited to memory cells. Moreover, calcium signals on T cells in response to MIP-3α were confined to CCR6-expressing cells, consistent with CCR6 being the only MIP-3α receptor on peripheral blood T cells. Unlike many CC chemokines, MIP-3α produced a calcium signal on freshly isolated T cells, and CCR6 expression was not increased by up to 5 days of treatment with IL-2 or by cross-linking CD3. Despite their surface expression of CCR6, freshly isolated B cells did not respond to MIP-3α. In addition to staining peripheral blood leukocytes, our anti-serum detected CCR6 on CD34+ bone marrow cell-derived dendritic cells. Our data are the first to analyze surface expression of CCR6, demonstrating receptor expression on differentiated, resting memory T cells, indicating differences in receptor signaling on T cells and B cells and suggesting that CCR6 and MIP-3α may play a role in the physiology of resting memory T cells and in the interactions of memory T cells, B cells, and dendritic cells." @default.
• W4313333699 created "2023-01-06" @default.
• W4313333699 creator A5027812169 @default.
• W4313333699 creator A5029312666 @default.
• W4313333699 creator A5033248260 @default.
• W4313333699 creator A5046335803 @default.
• W4313333699 creator A5058411478 @default.
• W4313333699 creator A5063107764 @default.
• W4313333699 date "1999-01-01" @default.
• W4313333699 modified "2023-10-16" @default.
• W4313333699 title "CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3α" @default.
• W4313333699 cites W1481674994 @default.
• W4313333699 cites W1483614591 @default.
• W4313333699 cites W1517124487 @default.
• W4313333699 cites W1539161723 @default.
• W4313333699 cites W1542489814 @default.
• W4313333699 cites W1561065423 @default.
• W4313333699 cites W1564046841 @default.
• W4313333699 cites W1568059997 @default.
• W4313333699 cites W1625203433 @default.
• W4313333699 cites W1661544713 @default.
• W4313333699 cites W1919579956 @default.
• W4313333699 cites W1960383875 @default.
• W4313333699 cites W1966010613 @default.
• W4313333699 cites W1971505103 @default.
• W4313333699 cites W1974005261 @default.
• W4313333699 cites W1974132609 @default.
• W4313333699 cites W1976905332 @default.
• W4313333699 cites W1980101887 @default.
• W4313333699 cites W1983466424 @default.
• W4313333699 cites W1984811742 @default.
• W4313333699 cites W1989035987 @default.
• W4313333699 cites W1994135361 @default.
• W4313333699 cites W1995358920 @default.
• W4313333699 cites W1998605540 @default.
• W4313333699 cites W2007348558 @default.
• W4313333699 cites W2026315125 @default.
• W4313333699 cites W2027344845 @default.
• W4313333699 cites W2034430377 @default.
• W4313333699 cites W2047719515 @default.
• W4313333699 cites W2059413226 @default.
• W4313333699 cites W2060294130 @default.
• W4313333699 cites W2060338116 @default.
• W4313333699 cites W2067714902 @default.
• W4313333699 cites W2071238735 @default.
• W4313333699 cites W2072424205 @default.
• W4313333699 cites W2073236988 @default.
• W4313333699 cites W2087372329 @default.
• W4313333699 cites W2089051402 @default.
• W4313333699 cites W2092280881 @default.
• W4313333699 cites W2103555767 @default.
• W4313333699 cites W2114123652 @default.
• W4313333699 cites W2117342688 @default.
• W4313333699 cites W2122794487 @default.
• W4313333699 cites W2124617998 @default.
• W4313333699 cites W2125630736 @default.
• W4313333699 cites W2129154410 @default.
• W4313333699 cites W2133147332 @default.
• W4313333699 cites W2138769023 @default.
• W4313333699 cites W2149764521 @default.
• W4313333699 cites W2152108405 @default.
• W4313333699 cites W2156936329 @default.
• W4313333699 cites W2157069655 @default.
• W4313333699 cites W2160129587 @default.
• W4313333699 cites W2161784528 @default.
• W4313333699 cites W2166982025 @default.
• W4313333699 cites W2171248814 @default.
• W4313333699 cites W2315695983 @default.
• W4313333699 cites W4313377103 @default.
• W4313333699 doi "https://doi.org/10.4049/jimmunol.162.1.186" @default.
• W4313333699 hasPublicationYear "1999" @default.
• W4313333699 type Work @default.
• W4313333699 citedByCount "230" @default.
• W4313333699 countsByYear W43133336992012 @default.
• W4313333699 countsByYear W43133336992013 @default.
• W4313333699 countsByYear W43133336992014 @default.
• W4313333699 countsByYear W43133336992015 @default.
• W4313333699 countsByYear W43133336992017 @default.
• W4313333699 countsByYear W43133336992018 @default.
• W4313333699 countsByYear W43133336992019 @default.
• W4313333699 countsByYear W43133336992020 @default.
• W4313333699 countsByYear W43133336992021 @default.
• W4313333699 countsByYear W43133336992022 @default.
• W4313333699 countsByYear W43133336992023 @default.
• W4313333699 crossrefType "journal-article" @default.
• W4313333699 hasAuthorship W4313333699A5027812169 @default.
• W4313333699 hasAuthorship W4313333699A5029312666 @default.
• W4313333699 hasAuthorship W4313333699A5033248260 @default.
• W4313333699 hasAuthorship W4313333699A5046335803 @default.
• W4313333699 hasAuthorship W4313333699A5058411478 @default.
• W4313333699 hasAuthorship W4313333699A5063107764 @default.
• W4313333699 hasBestOaLocation W43133336991 @default.
• W4313333699 hasConcept C116484652 @default.
• W4313333699 hasConcept C12823836 @default.
• W4313333699 hasConcept C128879288 @default.
• W4313333699 hasConcept C129013479 @default.
• W4313333699 hasConcept C13373296 @default.
• W4313333699 hasConcept C143172330 @default.

• next