FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333702> ?p ?o ?g. }

• W4313333702 endingPage "5264" @default.
• W4313333702 startingPage "5257" @default.
• W4313333702 abstract "Abstract The biological response to IL-12 is mediated through specific binding to a high affinity receptor complex composed of at least two subunits (designated IL-12Rβ1 and IL-12Rβ2) that are expressed on NK cells and activated T cells. The selective loss of IL-12Rβ2 expression during Th2 T cell differentiation suggests that regulation of this receptor component may govern IL-12 responsiveness. In murine assays, down-regulation of IL-12Rβ2 expression can be prevented by treatment with IFN-γ, indicating that receptor expression and hence IL-12 responsiveness may be regulated, at least in part, by the local cytokine milieu. In this study, we report that cellular expression of both IL-12Rβ1 and β2 mRNA is increased in the lymph nodes of naive mice following systemic administration of murine rIL-12 (rmIL-12). Changes in IL-12R mRNA were associated with increased IFN-γ secretion following ex vivo activation of lymph node cells with rmIL-12, indicating the presence of a functional receptor complex. Expression of IL-12R mRNA was not restricted to lymph node T cells, and its autocrine regulation was independent of secondary IFN-γ secretion. Data from fractionated lymph node cells as well as rmIL-12-treated B cell-deficient mice suggest that IL-12-responsive B cells may represent an alternative cellular source for IFN-γ production. However, the strength of the biological response to rmIL-12 is not governed solely by receptor expression, as rmIL-12-induced IFN-γ secretion from cultured lymph node cells is accessory cell dependent and can be partially blocked by inhibition of B7 costimulation." @default.
• W4313333702 created "2023-01-06" @default.
• W4313333702 creator A5006253493 @default.
• W4313333702 creator A5015593284 @default.
• W4313333702 creator A5016389673 @default.
• W4313333702 creator A5016925930 @default.
• W4313333702 creator A5024525935 @default.
• W4313333702 creator A5032657640 @default.
• W4313333702 creator A5079807059 @default.
• W4313333702 creator A5087974403 @default.
• W4313333702 creator A5088172050 @default.
• W4313333702 date "1999-11-15" @default.
• W4313333702 modified "2023-10-14" @default.
• W4313333702 title "Autocrine Regulation of IL-12 Receptor Expression Is Independent of Secondary IFN-γ Secretion and not Restricted to T and NK Cells" @default.
• W4313333702 cites W1505981109 @default.
• W4313333702 cites W1517852363 @default.
• W4313333702 cites W1524541469 @default.
• W4313333702 cites W1584684228 @default.
• W4313333702 cites W1598996496 @default.
• W4313333702 cites W1623924764 @default.
• W4313333702 cites W1656968650 @default.
• W4313333702 cites W1924633993 @default.
• W4313333702 cites W1929074972 @default.
• W4313333702 cites W1958745508 @default.
• W4313333702 cites W1981158471 @default.
• W4313333702 cites W1990098795 @default.
• W4313333702 cites W1991524518 @default.
• W4313333702 cites W1995991884 @default.
• W4313333702 cites W1996030543 @default.
• W4313333702 cites W1998295547 @default.
• W4313333702 cites W2006178861 @default.
• W4313333702 cites W2011499269 @default.
• W4313333702 cites W2023803780 @default.
• W4313333702 cites W2044325609 @default.
• W4313333702 cites W2046399828 @default.
• W4313333702 cites W2059433996 @default.
• W4313333702 cites W2067877107 @default.
• W4313333702 cites W2080674250 @default.
• W4313333702 cites W2096810938 @default.
• W4313333702 cites W2100763709 @default.
• W4313333702 cites W2107860814 @default.
• W4313333702 cites W2109506765 @default.
• W4313333702 cites W2126321883 @default.
• W4313333702 cites W2140944306 @default.
• W4313333702 cites W2142156809 @default.
• W4313333702 cites W2153552716 @default.
• W4313333702 cites W2157856892 @default.
• W4313333702 cites W4313308279 @default.
• W4313333702 cites W4313310005 @default.
• W4313333702 cites W4313333873 @default.
• W4313333702 cites W4313343474 @default.
• W4313333702 cites W4313379468 @default.
• W4313333702 doi "https://doi.org/10.4049/jimmunol.163.10.5257" @default.
• W4313333702 hasPublicationYear "1999" @default.
• W4313333702 type Work @default.
• W4313333702 citedByCount "14" @default.
• W4313333702 countsByYear W43133337022017 @default.
• W4313333702 crossrefType "journal-article" @default.
• W4313333702 hasAuthorship W4313333702A5006253493 @default.
• W4313333702 hasAuthorship W4313333702A5015593284 @default.
• W4313333702 hasAuthorship W4313333702A5016389673 @default.
• W4313333702 hasAuthorship W4313333702A5016925930 @default.
• W4313333702 hasAuthorship W4313333702A5024525935 @default.
• W4313333702 hasAuthorship W4313333702A5032657640 @default.
• W4313333702 hasAuthorship W4313333702A5079807059 @default.
• W4313333702 hasAuthorship W4313333702A5087974403 @default.
• W4313333702 hasAuthorship W4313333702A5088172050 @default.
• W4313333702 hasBestOaLocation W43133337021 @default.
• W4313333702 hasConcept C128240485 @default.
• W4313333702 hasConcept C134018914 @default.
• W4313333702 hasConcept C149532602 @default.
• W4313333702 hasConcept C154317977 @default.
• W4313333702 hasConcept C170493617 @default.
• W4313333702 hasConcept C202751555 @default.
• W4313333702 hasConcept C203014093 @default.
• W4313333702 hasConcept C2778690821 @default.
• W4313333702 hasConcept C2780849966 @default.
• W4313333702 hasConcept C2993002077 @default.
• W4313333702 hasConcept C49039625 @default.
• W4313333702 hasConcept C55493867 @default.
• W4313333702 hasConcept C86803240 @default.
• W4313333702 hasConcept C95444343 @default.
• W4313333702 hasConceptScore W4313333702C128240485 @default.
• W4313333702 hasConceptScore W4313333702C134018914 @default.
• W4313333702 hasConceptScore W4313333702C149532602 @default.
• W4313333702 hasConceptScore W4313333702C154317977 @default.
• W4313333702 hasConceptScore W4313333702C170493617 @default.
• W4313333702 hasConceptScore W4313333702C202751555 @default.
• W4313333702 hasConceptScore W4313333702C203014093 @default.
• W4313333702 hasConceptScore W4313333702C2778690821 @default.
• W4313333702 hasConceptScore W4313333702C2780849966 @default.
• W4313333702 hasConceptScore W4313333702C2993002077 @default.
• W4313333702 hasConceptScore W4313333702C49039625 @default.
• W4313333702 hasConceptScore W4313333702C55493867 @default.
• W4313333702 hasConceptScore W4313333702C86803240 @default.
• W4313333702 hasConceptScore W4313333702C95444343 @default.
• W4313333702 hasIssue "10" @default.
• W4313333702 hasLocation W43133337021 @default.

• next