FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333707> ?p ?o ?g. }

• W4313333707 endingPage "3142" @default.
• W4313333707 startingPage "3135" @default.
• W4313333707 abstract "Abstract The immunodominant T cell determinant of type II collagen (CII) recognized by DBA/1 mice (I-Aq) is CII 260–267. The aims of this study were to determine the role of the amino acid residues within CII 245–270 in T cell signal transduction. To that end, we utilized I-Aq-restricted, CII-specific T cell hybridomas and examined tyrosine phosphorylation of TCR-ζ following stimulation with either wild-type CII 245–270 or a panel of analogue peptides. A variety of patterns occurred, ranging from increased phosphorylation of TCR-ζ to either partial or a complete abrogation of phosphorylation. Critical substitutions also completely abrogated the phosphorylation of ZAP70, a downstream molecule in TCR-ζ signaling. Evaluation of the supernatants of the T cell hybridomas for cytokine production in response to the peptides revealed a close correlation between the induction of phosphorylation of TCR-ζ and the amount of cytokine induced. Selected analogue peptides were tested as tolerogens in neonatal mice. Analogues that did not induce the phosphorylation of ζ chain, such as B3 (CII 251–270s263F→N), were completely unable to induce tolerance, while analogues that caused a partial phosphorylation, such as B6 (CII 251–270s267Q→T) and A3 (CII 245–270s269P→A), induced partial tolerance judged by intermediate degrees of suppression of arthritis. We conclude that discrete alterations in specific amino acid residues of antigenic peptides had profound effects on T cell signaling and that the signaling correlated with T cell cytokine secretion and T cell function in the induction of tolerance and suppression of arthritis." @default.
• W4313333707 created "2023-01-06" @default.
• W4313333707 creator A5019474502 @default.
• W4313333707 creator A5032158017 @default.
• W4313333707 creator A5039556389 @default.
• W4313333707 creator A5052226142 @default.
• W4313333707 creator A5073800809 @default.
• W4313333707 creator A5078167371 @default.
• W4313333707 date "1998-04-01" @default.
• W4313333707 modified "2023-10-16" @default.
• W4313333707 title "Characterization of Signal Transduction Through the TCR-ζ Chain Following T Cell Stimulation with Analogue Peptides of Type II Collagen 260–267" @default.
• W4313333707 cites W1486648451 @default.
• W4313333707 cites W1495954528 @default.
• W4313333707 cites W1515780008 @default.
• W4313333707 cites W1519765807 @default.
• W4313333707 cites W1522465646 @default.
• W4313333707 cites W1559449746 @default.
• W4313333707 cites W1587792888 @default.
• W4313333707 cites W1594112875 @default.
• W4313333707 cites W1599213766 @default.
• W4313333707 cites W1671134765 @default.
• W4313333707 cites W1967234833 @default.
• W4313333707 cites W1967913927 @default.
• W4313333707 cites W1972974591 @default.
• W4313333707 cites W1976912963 @default.
• W4313333707 cites W1980990177 @default.
• W4313333707 cites W2002215388 @default.
• W4313333707 cites W2009597900 @default.
• W4313333707 cites W2009889274 @default.
• W4313333707 cites W2012694659 @default.
• W4313333707 cites W2014087668 @default.
• W4313333707 cites W2032169064 @default.
• W4313333707 cites W2042209841 @default.
• W4313333707 cites W2046901206 @default.
• W4313333707 cites W2050356515 @default.
• W4313333707 cites W2052561585 @default.
• W4313333707 cites W2058885870 @default.
• W4313333707 cites W2073626398 @default.
• W4313333707 cites W2078254067 @default.
• W4313333707 cites W2080476991 @default.
• W4313333707 cites W2084406139 @default.
• W4313333707 cites W2121507356 @default.
• W4313333707 cites W2131894799 @default.
• W4313333707 cites W2144935474 @default.
• W4313333707 cites W2148330408 @default.
• W4313333707 cites W2151151593 @default.
• W4313333707 cites W2500951108 @default.
• W4313333707 cites W4230500417 @default.
• W4313333707 cites W4248589410 @default.
• W4313333707 cites W78775163 @default.
• W4313333707 doi "https://doi.org/10.4049/jimmunol.160.7.3135" @default.
• W4313333707 hasPublicationYear "1998" @default.
• W4313333707 type Work @default.
• W4313333707 citedByCount "7" @default.
• W4313333707 countsByYear W43133337072016 @default.
• W4313333707 crossrefType "journal-article" @default.
• W4313333707 hasAuthorship W4313333707A5019474502 @default.
• W4313333707 hasAuthorship W4313333707A5032158017 @default.
• W4313333707 hasAuthorship W4313333707A5039556389 @default.
• W4313333707 hasAuthorship W4313333707A5052226142 @default.
• W4313333707 hasAuthorship W4313333707A5073800809 @default.
• W4313333707 hasAuthorship W4313333707A5078167371 @default.
• W4313333707 hasBestOaLocation W43133337071 @default.
• W4313333707 hasConcept C11960822 @default.
• W4313333707 hasConcept C153911025 @default.
• W4313333707 hasConcept C19317047 @default.
• W4313333707 hasConcept C203014093 @default.
• W4313333707 hasConcept C2776090121 @default.
• W4313333707 hasConcept C2777553839 @default.
• W4313333707 hasConcept C2778690821 @default.
• W4313333707 hasConcept C62478195 @default.
• W4313333707 hasConcept C86803240 @default.
• W4313333707 hasConcept C8891405 @default.
• W4313333707 hasConcept C95444343 @default.
• W4313333707 hasConceptScore W4313333707C11960822 @default.
• W4313333707 hasConceptScore W4313333707C153911025 @default.
• W4313333707 hasConceptScore W4313333707C19317047 @default.
• W4313333707 hasConceptScore W4313333707C203014093 @default.
• W4313333707 hasConceptScore W4313333707C2776090121 @default.
• W4313333707 hasConceptScore W4313333707C2777553839 @default.
• W4313333707 hasConceptScore W4313333707C2778690821 @default.
• W4313333707 hasConceptScore W4313333707C62478195 @default.
• W4313333707 hasConceptScore W4313333707C86803240 @default.
• W4313333707 hasConceptScore W4313333707C8891405 @default.
• W4313333707 hasConceptScore W4313333707C95444343 @default.
• W4313333707 hasIssue "7" @default.
• W4313333707 hasLocation W43133337071 @default.
• W4313333707 hasOpenAccess W4313333707 @default.
• W4313333707 hasPrimaryLocation W43133337071 @default.
• W4313333707 hasRelatedWork W1504553252 @default.
• W4313333707 hasRelatedWork W1986771544 @default.
• W4313333707 hasRelatedWork W2015719811 @default.
• W4313333707 hasRelatedWork W2042759576 @default.
• W4313333707 hasRelatedWork W2115362188 @default.
• W4313333707 hasRelatedWork W2120071583 @default.
• W4313333707 hasRelatedWork W2127080319 @default.
• W4313333707 hasRelatedWork W2151611145 @default.
• W4313333707 hasRelatedWork W4313333707 @default.

• next